Capsules · 60 capsules · 60 servings · $0.48/serving
Serving Size:
1 Capsule
Amount Per Serving:
Berberine HCl ... 500mg
(97%)(from Berberis vulgaris extract)(seed)
Other Ingredients:
100% Vegetarian Capsule (cellulose, gellan gum, water), rice concentrate
Does not contain gluten, milk, casein, soy, egg, artificial colors or flavors.
Consult with a physician prior to use if you are pregnant or nursing, taking medications or have a medical condition.
1 capsule before meals with a glass of water
Ingredient information is provided above. A clear label image is not available yet.
View original supplier image (quality may be limited)Source: Fullscript supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Enzymedica Berberine delivers berberine hydrochloride, an alkaloid compound derived from plants such as barberry and goldenseal, formulated to support healthy blood sugar metabolism, cardiovascular function, and gut microbiome balance. It's well-suited for adults seeking metabolic and digestive wellness support.
Why It's Worth Considering: Enzymedica pairs berberine with their enzyme delivery technology, which may enhance absorption and reduce the GI discomfort sometimes associated with standard berberine formulations.
1 capsule before meals with a glass of water
Head-to-head clinical trials show berberine 500mg 3x/day produces comparable HbA1c reduction (0.5-0.9%) and fasting glucose reduction to metformin 500mg 3x/day. Berberine also reduces LDL cholesterol and triglycerides, an effect metformin doesn't have. However, berberine is a supplement, not a drug, and should not replace prescribed medication without physician guidance.
Take 500mg 2-3 times daily with meals. The key is splitting the dose, berberine has a short half-life (~5 hours) and taking it with each meal maximizes the post-meal blood sugar benefit. Start with 500mg once daily and increase over 2 weeks to reduce GI side effects (which are similar to metformin).
Common: GI discomfort, diarrhea, constipation, gas (similar to metformin, usually resolves in 1-2 weeks). Berberine can lower blood sugar significantly, monitor if diabetic. It also inhibits CYP3A4 liver enzyme, which affects metabolism of many drugs (statins, blood thinners, antidepressants). Check drug interactions carefully.
Most studies are 3-6 months. Some practitioners recommend cycling: 8 weeks on, 4 weeks off, to maintain effectiveness and allow the gut microbiome to rebalance (berberine has antimicrobial properties). Long-term continuous use appears safe in studies up to 2 years, but cycling is a reasonable precaution.
Apotheca is analyzing ingredient interactions, stacking compatibility, and timing recommendations for Enzymedica - Berberine. This data will be available soon.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
