Integrative Therapeutics

Similase GFCF, 120 Capsules

Similase GFCF by Integrative Therapeutics is a targeted digestive enzyme blend formulated to support the breakdown of gluten and casein, proteins found in wheat and dairy, along with broader carbohydrate and protein digestion.

4.6 across 2 sources

May be a fit for

  • Adults managing gluten and casein sensitivity through enzyme-based digestive support
  • Individuals seeking digestive enzyme assistance when navigating gluten-containing foods
  • Practitioners protocols requiring multi-enzyme formulas targeting gluten and casein breakdown
$35.99

30-day money-back guarantee
Save together with Wellness Circles

Invite friends or family to a Wellness Circle. Your group can unlock savings together. See current tiers and terms before joining.

Explore Wellness Circles
CapsulesFormat
120 CapsulesPack size
The essentials

A closer look.

Similase GFCF by Integrative Therapeutics is a targeted digestive enzyme blend formulated to support the breakdown of gluten and casein, proteins found in wheat and dairy, along with broader carbohydrate and protein digestion. It features a multi-enzyme complex including DPP-IV activity, which plays a key role in hydrolyzing proline-rich peptide sequences common in gluten and casein. It's designed for individuals who follow or are transitioning to a gluten-free, casein-free diet and want added digestive support.

Why It's Worth Considering: Integrative Therapeutics is a practitioner-grade brand with a strong track record in clinical enzyme formulation; the inclusion of DPP-IV activity alongside a broad-spectrum enzyme profile sets this apart from general digestive enzyme products.

The Apotheca perspective

50+ signals. A clearer standard.

Our curation and trust scoring bring together manufacturing, testing, research, practitioner insight and reviews from across the web.

89OUT OF 100
Manufacturing9797
Lab verification7070
Transparency6666

Our score is an editorial assessment, not a product certification or a guarantee of results.

Inside the formula

Product details

Who it may suit

May be a fit for

  • Adults managing gluten and casein sensitivity through enzyme-based digestive support
  • Individuals seeking digestive enzyme assistance when navigating gluten-containing foods
  • Practitioners protocols requiring multi-enzyme formulas targeting gluten and casein breakdown
  • Those supporting gut comfort after accidental gluten or dairy exposure

Considerations

  • Known allergy to any ingredient (check label)
  • Currently pregnant or breastfeeding (consult healthcare provider)
  • Taking prescription medications (check for interactions)
  • Under 18 years of age (unless recommended by pediatrician)
From across the web

Real reviews. A wider perspective.

Customer reviews, social conversations and expert insights, with every source in view.

4.6/5Aggregate source rating
Marketplaces & brand websites
Amazon, iHerb and direct brand reviews
Social & community
Reddit, X, Instagram and TikTok
Video & creators
YouTube and creator perspectives

Coverage varies by product and brand.

886 product and brand ratings and mentions across 2 sources.

Explore the source sentiment summary

Integrative Therapeutics is highly trusted by both practitioners and users, with consistent positive reports across digestive and wellness products.

This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.

Good to know

A few useful answers.

Research & further reading

More category questions

How should I store this supplement?

Store in a cool, dry place away from direct sunlight. Most supplements are stable at room temperature (59-77°F). Keep the bottle sealed between uses. Check the label for any specific storage requirements — some probiotics and oils require refrigeration.

Can I take this with other supplements?

Most supplements can be taken together safely. However, some minerals compete for absorption (zinc and iron, calcium and magnesium) and should be taken at different times of day. If you're taking prescription medications, consult your healthcare provider about potential interactions.

How long should I take this supplement?

Most supplements benefit from consistent daily use over 2-3 months to achieve full effect. Some (like vitamins and minerals) can be taken indefinitely as part of a daily routine. Others (like specific herbs) may benefit from cycling. Follow the product's recommended protocol or consult a practitioner.

When is the best time to take this?

Fat-soluble supplements (vitamins A, D, E, K, omega-3, CoQ10) should be taken with a meal containing fat. Water-soluble supplements (B vitamins, vitamin C) can be taken anytime. Minerals are generally best absorbed with food. Probiotics should be taken with or just before a meal. Check the product label for specific timing recommendations.

How do I know if this supplement is working?

Track your specific health goals — energy levels, sleep quality, joint comfort, digestion, mood, etc. Most supplements take 2-8 weeks for noticeable effects. For objective measurement, baseline lab tests before starting (and repeat at 3 months) provide definitive evidence. The Gabriel Score incorporates clinical evidence for expected outcomes.

Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.

Integrative Therapeutics - Similase GFCF, 120 Capsules Integrative Therapeutics

Apotheca quality score

89/100

The overall score combines several sources of information. The individual dimensions below show where those signals are stronger or more limited; they are not a simple average of the overall score.

Manufacturing9797
Lab verification7070
Review consensus98.898.8
Practitioner signals58.058.0
Community signals6868
Transparency6666
See available brand signals
✓
Third-party lab tested (heavy metals, contaminants)Pass
✓
GMP-certified manufacturing by Integrative TherapeuticsCertified
✓
Premium ingredient sourcing with bioavailable formsHigh
✓
Clinical evidence available for primary ingredientsAvailable
✓
Clean FDA regulatory recordNo issues
✓
Positive consumer reviews and community feedbackGood
✓
Authorized distribution channel verifiedDirect

Our score is an editorial assessment, not a product certification or a guarantee of results.

How our scoring works ↗