E-400 Selenium™, 60 Tablets
Metagenics E-400 Selenium™ combines vitamin E (as d-alpha tocopherol) at 400 IU with selenium, two nutrients that work synergistically to support antioxidant defense and healthy cellular function.
May be a fit for
- Adults seeking vitamin E and selenium antioxidant support together
- Practitioners protocols requiring combined tocopherol and selenium dosing
- Individuals supporting cellular protection with mixed tocopherol forms
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Metagenics E-400 Selenium™ combines vitamin E (as d-alpha tocopherol) at 400 IU with selenium, two nutrients that work synergistically to support antioxidant defense and healthy cellular function. Formulated for adults seeking foundational antioxidant support, this pairing reflects a practitioner-oriented approach to nutrient synergy.
Why It's Worth Considering: Metagenics uses d-alpha tocopherol, the natural form of vitamin E with higher biological activity than synthetic dl-alpha tocopherol, alongside selenium to support the body's glutathione peroxidase pathways.
Product details
Who it may suit
May be a fit for
- Adults seeking vitamin E and selenium antioxidant support together
- Practitioners protocols requiring combined tocopherol and selenium dosing
- Individuals supporting cellular protection with mixed tocopherol forms
- Those maintaining selenium status alongside fat-soluble vitamin E intake
Considerations
- Already consuming high-selenium foods daily (Brazil nuts)
- Doses above 400mcg/day (selenosis risk)
- Non-melanoma skin cancer history (some concern with high-dose Se)
Compatibility & interactions
Works Well With
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Take Separately From
No significant interactions identified. Always consult your healthcare provider.
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A few useful answers.
Research & further reading
More category questions
How much selenium should I take?
For maintenance: 100-200mcg daily (selenomethionine form preferred). For thyroid support: 200mcg. The RDA is 55mcg but most functional medicine practitioners recommend 100-200mcg. Do NOT exceed 400mcg/day — selenium has a narrow therapeutic window and excess causes selenosis (hair loss, nail brittleness, GI issues).
Is selenium good for thyroid?
Yes — selenium is critical for thyroid function. It's required for the enzyme that converts inactive T4 to active T3, AND it protects thyroid cells from oxidative damage. In Hashimoto's, 200mcg selenium daily reduces TPO antibodies by 20-40% in clinical trials. It's one of the most evidence-based supplements for thyroid health.
Can I just eat Brazil nuts instead?
One Brazil nut contains 70-90mcg selenium — so 2 nuts/day provides a therapeutic dose. However, selenium content varies dramatically by soil (some nuts have 10mcg, others have 300mcg). If you rely on Brazil nuts, be cautious about overconsumption — 4-5 large nuts could exceed 400mcg. A supplement provides a consistent, known dose.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.