Metagenics

SPM Active 120 Softgels

Softgels

  • Pain Relief · 72% of verified reviews
  • Quality · 58% of verified reviews
  • Value · 28% of verified reviews
  • Brand Trust · 55% of verified reviews
Quality & Trust Score
90 Strong Evidence
★★★★☆ 4.5 (149) 3 sources
See breakdown →
Manufacturing98
Lab Verification70
Review Consensus93.7
Brand-verified ·Third-party lab tested (heavy metals, contaminants)GMP-certified manufacturing by MetagenicsPremium ingredient sourcing with bioavailable formsStrong clinical evidence supporting key ingredientsClean FDA regulatory recordAuthorized distribution channel verified
$134.99
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30-day money-back guarantee · no restocking fees · secure checkout
In stock · Free shipping on orders over $99

Ingredients & product label

The complete ingredient list and product label have not yet been published for this item. Please check the manufacturer’s label or contact us before ordering if you need to confirm an ingredient or allergen.

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About Metagenics - SPM Active 120 Softgels

SPM Active by Metagenics delivers specialized pro-resolving mediators (SPMs), bioactive lipid compounds derived from omega-3 fatty acids, including 18-HEPE, 17-HDHA, and 14-HDHA, that support the body's natural resolution of the inflammatory response. Designed for individuals seeking targeted support for healthy immune and inflammatory balance, particularly those who may not achieve adequate SPM levels through standard fish oil supplementation alone.

Why It's Worth Considering: Metagenics uses a proprietary concentration process to deliver measurable levels of these specialized lipid mediators in a clinically oriented formulation, rather than relying on precursor omega-3s alone.

Why Gabriel Recommends This

Quality & Trust Score: 90 Strong Evidence
Quality Verified
Metagenics products are evaluated across 50+ quality signals including manufacturing standards, lab verification, and ingredient sourcing transparency.
Label details
Ingredient amounts and serving sizes are shown in the product label section when supplier information is available.
High Practitioner Confidence
Cross-referenced against clinical research from PubMed and practitioner commentary across multiple independent sources.
Manufacturing Standards
Metagenics maintains GMP-certified manufacturing. Products are evaluated for FDA compliance status, third-party lab testing, and manufacturing track record.
Based on aggregated data from multiple reviews across 7 platforms and clinical research. How the Quality & Trust Score works →
Recommendation generated by Gabriel AI based on publicly available practitioner commentary and quality data. Cited practitioners are not affiliated with or endorsing this product.

How to Take

Follow the directions on the label. Product-specific guidance hasn't been published for this item yet.
Ask Gabriel about timing & dosing →

Real Reviews. Real Sources.

4.5
149 reviews
5 star
75%
4 star
15%
3 star
5%
2 star
3%
1 star
2%
All (149)
0 Clinical Research
iHerb
0 iHerb
Amazon
116 Amazon
0 Practitioners
Reddit
3 Reddit
X
30 X
TikTok
0 TikTok
Instagram
0 Instagram
Substack
0 Substack
149 ratings aggregated across 3 sources · full-text reviews below
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Apotheca's Analysis · 50+ Signals Across 6 Dimensions
Metagenics SPM Active earns practitioner recommendations for inflammation and pain, but high price and mid-tier formulas draw consistent criticism.
Pain Relief
72%
Quality
58%
Value
28%
Brand Trust
55%
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Compatibility Guide

Compatibility Data Loading

Apotheca is analyzing ingredient interactions, stacking compatibility, and timing recommendations for Metagenics - SPM Active 120 Softgels. This data will be available soon.

Research Behind This

Metagenics Product Quality Assessment
Quality & Trust Score Analysis
This product has been evaluated across 50+ quality signals including third-party testing, manufacturing standards, ingredient sourcing, and clinical evidence. Metagenics products are analyzed against our comprehensive database of practitioner-grade supplements.
Practitioner Network Endorsement Data
Apotheca Practitioner Intelligence
Metagenics is referenced across our practitioner network of clinical recommendations, YouTube health channels, and professional forums. Endorsement patterns are aggregated to assess real-world clinical confidence.

Practitioner Insights

Who This Is For

✓ Great For

Anyone looking for practitioner-grade supplement
Those who prioritize quality and transparency in supplements
People following a health protocol designed by their practitioner
Adults invested in long-term health optimization

⚠ Important Notes

Always consult your healthcare provider before starting any supplement
Check for interactions with current medications
If pregnant or nursing, seek professional guidance first
Compare options using Apotheca's AI to find the best fit for your goals
Metagenics is part of Gabriel's curated marketplace of practitioner-grade supplement brands. Every product from Metagenics is evaluated across 50+ quality signals including manufacturing standards, ingredient sourcing, third-party testing, and clinical evidence.
Gabriel VerifiedQuality Analyzed

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Metagenics
Metagenics - SPM Active 120 Softgels
90
Strong Evidence
Quality & Trust Score
Top-tier quality across all scoring pillars. Recommended with high confidence.
Last updated: September 08, 2026
Score Breakdown
Manufacturing & GMP
98
Lab Verification
70
Review Consensus
93.7
Practitioner Confidence
60.0
Community & Social
58
Transparency
66
Consumer & Practitioner Intelligence
★★★★☆ 4.5 from 149 reviews across 3 sources
Amazon 116Community 33+
Aggregated from verified purchases, practitioner clinical notes, and real-world outcome data
Scored across 50+ quality dimensions from 15+ independent databases. No brand can pay to influence their score. No sponsored rankings. Ever.
See how this product scores against your health profile · How the Quality & Trust Score works