Microbiome Labs

MegaMarine (formerly Gut-Specific Fish Oil), 60 Softgels

MegaMarine by Microbiome Labs is a concentrated fish oil formulated specifically to support gut mucosal integrity and a balanced intestinal environment.

May be a fit for

  • Adults seeking omega-3 fish oil formulated specifically for gut lining support
  • Those following gut-focused protocols requiring marine-sourced EPA and DHA
  • Individuals looking to maintain intestinal mucosal integrity with fish oil
$58.99

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SoftgelsFormat
60 SoftgelsPack size
The essentials

A closer look.

MegaMarine by Microbiome Labs is a concentrated fish oil formulated specifically to support gut mucosal integrity and a balanced intestinal environment. Delivering EPA and DHA in a targeted, gut-focused context, it's designed for individuals seeking omega-3 support that goes beyond cardiovascular wellness to address the gastrointestinal lining.

Why It's Worth Considering: Unlike standard fish oils, MegaMarine is formulated with the gut microbiome in mind, reflecting Microbiome Labs' practitioner-oriented research focus, making it a thoughtful option for clinicians and patients working on digestive health protocols.

Inside the formula

Product details

Who it may suit

May be a fit for

  • Adults seeking omega-3 fish oil formulated specifically for gut lining support
  • Those following gut-focused protocols requiring marine-sourced EPA and DHA
  • Individuals looking to maintain intestinal mucosal integrity with fish oil
  • Practitioner protocols combining omega-3s with microbiome restoration strategies

Considerations

  • Fish/shellfish allergy (use algal omega-3 instead)
  • Taking blood thinners (consult physician — may enhance effect)
  • Scheduled surgery within 2 weeks (may increase bleeding)
  • Bleeding disorders
Compatibility & interactions

Works Well With

CoQ10
Both support cardiovascular health
Turmeric
Complementary anti-inflammatory pathways
Vitamin D3
Both fat-soluble, support immunity

Take Separately From

No significant interactions identified. Always consult your healthcare provider.

What to expect over time
Week 1–4

Cell Membrane Integration

EPA/DHA incorporate into cell membranes

Week 4–8

Inflammation Markers

Measurable CRP reduction

Month 2–3

Joint & Mood

Reduced joint stiffness, improved mood

Month 3–6

Cardiovascular

Triglycerides reduced 15-30%

Based on clinical research on EPA/DHA supplementation at therapeutic doses (2-4g combined EPA+DHA).

Compare the options

Compare Omega-3 Sources

Fish Oil vs Krill vs Algal vs Cod Liver

FeatureFish Oil (this)Krill OilAlgal OilCod Liver Oil
EPA+DHA ContentHigh (concentrated)ModerateModerate-HighModerate + Vit A/D
AbsorptionGood (triglyceride form)Excellent (phospholipid)GoodGood + fat-soluble vitamins
Best ForTherapeutic dose, heart/brainGeneral wellnessVegan optionVitamin A+D + omega-3
SustainabilityVaries by brandSustainable harvestMost sustainableTraditional, sustainable
Burp FactorLow (if enteric coated)Very lowNoneModerate
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Good to know

A few useful answers.

Research & further reading

More category questions

How much fish oil should I take daily?

For general health, 1-2g of combined EPA+DHA daily. For therapeutic use (triglycerides, inflammation, mood), 2-4g combined EPA+DHA. Check the label for EPA+DHA content per serving — many fish oils have only 300mg per 1000mg capsule, requiring 6-8 capsules for a therapeutic dose. Concentrated formulas provide 600-900mg per capsule.

What is the difference between EPA and DHA?

EPA (eicosapentaenoic acid) is primarily anti-inflammatory — best for joint pain, cardiovascular health, and mood disorders. DHA (docosahexaenoic acid) is structural — it comprises 40% of brain polyunsaturated fats and is critical for cognitive function, eye health, and fetal development. Most people benefit from both; higher EPA for inflammation, higher DHA for brain health.

Does fish oil cause fishy burps?

Low-quality fish oil can cause fishy aftertaste and burping. Solutions: take with food, choose enteric-coated capsules, refrigerate the bottle (slows breakdown), or use a concentrated triglyceride-form fish oil (higher quality = less burping). If you still experience burps, the oil may be oxidized — check the expiration date and smell the capsule.

Is krill oil better than fish oil?

Krill oil has better absorption per gram (phospholipid form) and contains astaxanthin (antioxidant), but it's significantly more expensive per mg of EPA+DHA. For therapeutic doses (2-4g EPA+DHA), fish oil is more practical and cost-effective. Krill oil is a good choice for general wellness at maintenance doses.

Can I take fish oil with blood thinners?

Fish oil has mild blood-thinning properties. If you're taking warfarin, aspirin, or other anticoagulants, consult your physician before starting high-dose omega-3. At standard doses (1-2g), the risk is low, but your INR may need monitoring. Stop fish oil 1-2 weeks before scheduled surgery.

How do I choose a quality fish oil?

Look for: third-party tested for heavy metals and oxidation (IFOS 5-star rated), triglyceride form (not ethyl ester), high EPA+DHA per capsule (600mg+ combined), and molecular distillation for purity. The Gabriel Score evaluates all of these quality signals automatically.

Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.

Microbiome Labs - MegaMarine (formerly Gut-Specific Fish Oil), 60 Softgels