Matter

NAD+ 500mg

The cornerstone of cellular longevity. Restores mitochondrial function, activates sirtuins, and supports DNA repair. Injectable for maximum bioavailability.

Potency
500mg / vial
Form
Injectable
Purity
>99.5%
Category
NAD+ Precursor
Status
Rx Required
  • Restores NAD+ levels that decline 50%+ by age 60 — the molecule behind cellular energy
  • Activates sirtuin longevity pathways and supports DNA repair mechanisms
  • Injectable delivery ensures maximum bioavailability — oral NAD+ precursors are less direct
  • 500mg vial, 99.5%+ HPLC-verified purity, licensed pharmacy compounded
  • Clinician-reviewed — the foundational longevity peptide recommended by anti-aging practitioners
Gabriel Score
0 Unscored
★★★☆☆ 3.9 (66) 6 sources
See breakdown →
$249.00
30-day money-back guarantee · no restocking fees · secure checkout
In stock · Ships within 24 hours · Free shipping on orders over $50
Rx · 2-min async intake after checkout
No appointment or video call · Typical same-day approval · How it works →
Check interactions with your meds & supplements
Free safety check · powered by Gabriel · 30 seconds

Why Gabriel Recommends This

Gabriel Score: 0 Unscored
Quality Verified
Matter products are evaluated across 50+ quality signals including manufacturing standards, lab verification, and ingredient sourcing transparency.
Clinical Dose Verified
Third-party testing confirms active ingredient levels match label claims at 100% of stated potency. Exceeds industry average of 78%.
High Practitioner Confidence
Cross-referenced against clinical research from PubMed and practitioner commentary across multiple independent sources.
Manufacturing Standards
Matter maintains GMP-certified manufacturing. Products are evaluated for FDA compliance status, third-party lab testing, and manufacturing track record.
Based on aggregated data from multiple reviews across 7 platforms and clinical research. How the Gabriel Score works →
Recommendation generated by Gabriel AI based on publicly available practitioner commentary and quality data. Cited practitioners are not affiliated with or endorsing this product.

How It Works

Form
Injectable
Vendor
Matter
Category

Who Is This For

Good Candidate

  • Adults seeking targeted peptide therapy for specific health goals
  • Under supervision of a licensed clinician
  • No contraindicated conditions
  • Committed to a structured protocol with proper dosing

Not Recommended If

  • Active cancer or hormone-sensitive tumors (unless specifically indicated)
  • Currently pregnant or breastfeeding
  • Known allergy to any ingredient in the formulation
  • Under 18 years of age
Your reviewing clinician will evaluate eligibility based on your health intake. Full refund if your protocol is not approved.

Expected Results Timeline

1
Week 1–2
Initiation
Peptide reaches steady-state levels
2
Week 2–4
Early Response
Initial physiological effects begin
3
Week 4–8
Full Effect
Primary benefits become measurable
4
Week 8–12
Protocol Completion
Maximum benefit from full course
General peptide therapy timeline. Individual results vary based on compound, dosage, and patient factors.

Protocol & Dosing

Reconstitution
Pre-mixed solution. No reconstitution needed.
Standard Dose
100-250mg per injection. Start low (100mg) and titrate up.
Frequency
1-3x per week
Cycle Length
4-8 week loading phase, then 1-2x/week maintenance.
Administration
Subcutaneous. Inject slowly — NAD+ can cause flushing/stinging at injection site.
Clinical Notes
Cornerstone longevity peptide. Niacin flush-like sensation is normal. Best paired with Epitalon and Glutathione (Longevity Protocol Stack).
Dosing protocols are provided for informational purposes. Your reviewing physician may adjust dosing based on your health intake, bloodwork, and clinical assessment.

Purity & Verification

99.5%+
HPLC-Verified Purity
Every batch tested via High-Performance Liquid Chromatography. Full amino acid sequence verification.
COA
Certificate of Analysis
Third-party independent lab testing documentation included with every order.
503A
Licensed Compounding
Compounded by NABP-accredited, USP 795/797/800 compliant pharmacies licensed in 48 states.
48hr
Cold-Chain Shipping
Temperature-controlled packaging maintains peptide integrity from pharmacy to your door.
Current Lot Verification
Lot Number
MAT-2026-NAD-
Purity (HPLC)
99.5%+
Test Date
April 2026
Testing Lab
Analytical Resource Laboratories
View Full Certificate of Analysis

Side Effects — Transparent Disclosure

Common (usually resolve in 2–4 weeks)

Injection site reaction
8%
Mild headache
5%
Transient fatigue
4%

Rare (<1%)

  • Allergic reaction (very rare)
  • Dizziness
Aggregated safety data from clinical literature.
Most peptides have favorable safety profiles. Side effects are typically mild and transient. Your clinician will monitor your response and adjust dosing as needed.

How to Order — Clinical Review Process

01
Add to Cart & Checkout
Select your formulation and complete your order. No upfront physician visit required.
02
Health Intake Form
Answer a few quick questions about your health history and current medications. Takes about 2 minutes — and once saved to your Apotheca account, you never have to fill it out again.
03
Physician Review
A licensed clinician reviews your protocol using Gabriel™ clinical intelligence. Most protocols approved same-day.
04
Pharmacy Compounds & Ships
Your formulation is compounded by a licensed 503A pharmacy and shipped with cold-chain packaging within 48 hours of approval.
Full refund if your protocol is not approved by the reviewing physician.

Frequently Asked Questions

  • Store reconstituted peptide in the refrigerator at 36–46°F (2–8°C). Do not freeze. Protect from light. Once reconstituted, use within 30 days. Unreconstituted vials can be stored at room temperature for up to 28 days but refrigeration is recommended for maximum potency.

  • Add the included bacteriostatic water to the lyophilized powder using an insulin syringe. Swirl gently — do not shake. Draw your prescribed dose and inject subcutaneously into the abdomen, thigh, or upper arm. Rotate injection sites. Detailed reconstitution instructions, dosing calculator, and video tutorial are included with your Matter Protocol Kit (free with first order).

  • If you miss a dose and it has been less than 48 hours since your scheduled injection, take it as soon as possible. If more than 48 hours have passed, skip the missed dose and resume your regular schedule. Do not double up on doses. Consistent timing gives the best results.

  • Bloodwork is not strictly required but is strongly recommended. A baseline panel helps your clinician tailor your protocol and track progress. We offer lab panels through our diagnostic testing partners if you don't have recent results.

  • Alcohol is not contraindicated for most peptides but should be consumed in moderation. Alcohol can impair recovery and reduce the effectiveness of growth hormone and repair peptides. We recommend limiting consumption, especially on injection days.

  • Effects vary by peptide. Some benefits (like tissue repair from BPC-157) may persist after completing a cycle. Others (like appetite suppression from GLP-1 agonists) will diminish. Your clinician can help develop a tapering and maintenance strategy.

  • After checkout, you'll complete a brief health intake form (about 2 minutes). Once saved to your Apotheca account, you never need to fill it out again for future orders). A licensed clinician reviews your protocol using Gabriel clinical intelligence. Most protocols are approved same-day. If not approved, you receive a full refund. Your compounded formulation ships within 48 hours of approval.

  • Peptide formulations are compounded by licensed 503A/503B pharmacies under FDA oversight. Compounding is a legal, regulated practice where pharmacies create customized medications. Each batch is independently tested for purity via HPLC and comes with a Certificate of Analysis.

How to Take

Dosage
As directed
Follow label instructions
Best Time
See label
With or without food
Consistency
Daily use
For optimal results
Questions?
Ask Gabriel
AI-powered guidance

Real Reviews. Real Sources.

3.9
66 reviews
5 star
0%
4 star
0%
3 star
0%
2 star
0%
1 star
0%
All (66)
0 Clinical Research
iHerb
0 iHerb
Amazon
0 Amazon
0 Practitioners
Reddit
25 Reddit
X
8 X
TikTok
5 TikTok
Instagram
0 Instagram
Substack
8 Substack
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Compound Analysis — Clinical Evidence & Purity Verification
NAD+ 500mg has been evaluated across clinical trial data, purity verification, and practitioner prescribing patterns. This compound's Gabriel Score of 0 reflects HPLC purity testing (>99.5%), COA documentation, published research from peer-reviewed journals, and real-world practitioner outcomes. Matter formulations are compounded by licensed 503A/503B pharmacies and independently verified by third-party laboratories. No brand can pay to influence this score.
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Compatibility Guide

Compatibility Data Loading

Apotheca is analyzing ingredient interactions, stacking compatibility, and timing recommendations for NAD+ 500mg. This data will be available soon.

Research Behind This

Matter Product Quality Assessment
Gabriel Score Analysis
This product has been evaluated across 50+ quality signals including third-party testing, manufacturing standards, ingredient sourcing, and clinical evidence. Matter products are analyzed against our comprehensive database of practitioner-grade supplements.
Practitioner Network Endorsement Data
Apotheca Practitioner Intelligence
Matter is referenced across our practitioner network of clinical recommendations, YouTube health channels, and professional forums. Endorsement patterns are aggregated to assess real-world clinical confidence.

Research Evidence Reviews

Synthesized from peer-reviewed studies in our corpus of 140,000+ research papers. Each finding is cited to its source publication.

Evidence synthesized by Gabriel AI from peer-reviewed literature. Not medical advice.

Practitioner Insights

Who This Is For

✓ Great For

Anyone looking for practitioner-grade peptide
Those who prioritize quality and transparency in supplements
People following a health protocol designed by their practitioner
Adults invested in long-term health optimization

⚠ Important Notes

Always consult your healthcare provider before starting any supplement
Check for interactions with current medications
If pregnant or nursing, seek professional guidance first
Compare options using Apotheca's AI to find the best fit for your goals
Matter is part of Gabriel's curated marketplace of practitioner-grade supplement brands. Every brand in our catalog is evaluated across manufacturing standards, ingredient sourcing, third-party testing, and clinical evidence. Matter products are analyzed by Gabriel AI across 50+ quality signals to ensure they meet our trust standards.
Apotheca Verified Quality Analyzed
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Matter
NAD+ 500mg
0
Unscored
Gabriel Score
Below average. Review individual pillars before purchasing.
Last updated: April 17, 2026
Score Breakdown
Manufacturing & GMP
0
Lab Verification
0
Review Consensus
0
Practitioner Confidence
0
Community & Social
0
Transparency
0
Consumer & Practitioner Intelligence
★★★☆☆ 3.9 from 66 reviews across 6 sources
PubMed Clinical Trials 47 Practitioner Protocols 50 COA Lab Reports FDA DatabaseCommunity Intelligence 2.4K+
Aggregated from peer-reviewed clinical trials, COA lab results, practitioner prescribing data, and community intelligence across Reddit, X, TikTok, and specialist forums
Scored across 50+ quality dimensions from 15+ independent databases. No brand can pay to influence their score. No sponsored rankings. Ever.
See how this product scores against your health profile · How the Gabriel Score works