Methyl-Plex B™, 60 Capsules
Methyl-Plex B™ from NuMedica is a B-vitamin complex formulated with methylated forms of key nutrients, including methylcobalamin (B12) and methylfolate (5-MTHF), designed to support methylation pathways, energy metabolism, and nervous system function.
May be a fit for
- Adults seeking active methylated B vitamins for daily metabolism support
- Individuals with MTHFR variants who may benefit from methylfolate forms
- Those supporting healthy homocysteine levels with methyl-B12 and methylfolate
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Methyl-Plex B™ from NuMedica is a B-vitamin complex formulated with methylated forms of key nutrients, including methylcobalamin (B12) and methylfolate (5-MTHF), designed to support methylation pathways, energy metabolism, and nervous system function. It's particularly suited for individuals with MTHFR gene variants or those who may have difficulty converting standard B vitamins into their active forms.
Why It's Worth Considering: The use of pre-converted, bioavailable coenzyme forms bypasses common metabolic conversion steps, making this formula relevant for practitioners addressing methylation support in sensitive or complex cases.
NuMedica · 60 CapsulesMake it part of your routine.
Take one capsule once per day with a meal or as directed by your healthcare practitioner.
Important cautions & interactions
Product details
Supplement facts & complete label
Serving Size:
1 Capsule
Servings per container: 60
Amount Per Serving:
Riboflavin (Vitamin B2) (as riboflavin-5'-phosphate) ... 25 mg
Vitamin B6 (as pyridoxal-5'-phosphate) ... 25 mg
Folate ... 2,040 mcg DFE
(as 600 mcg (6S)-5-methyltetrahydrofolic acid, glucosamine salt*, and 600 mcg (6S)-5-methyltetrahydrofolic acid, calcium salt)
Vitamin B12 (as methylcobalamin) ... 1,000 mcg
Trimethylglycine (as anhydrous betaine) ... 500 mg
Other Ingredients:
Hydroxypropyl methylcellulose (vegetable capsule), magnesium stearate, silicon dioxide.
Label directions
Take one capsule once per day with a meal or as directed by your healthcare practitioner.
Label cautions
Keep out of reach of children. Keep tightly closed in a cool, dry place.
Source: authorized supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking active methylated B vitamins for daily metabolism support
- Individuals with MTHFR variants who may benefit from methylfolate forms
- Those supporting healthy homocysteine levels with methyl-B12 and methylfolate
- People seeking bioavailable B-complex without synthetic folic acid
Considerations
- Known allergy to any ingredient (check label)
- Currently pregnant or breastfeeding (consult healthcare provider)
- Taking prescription medications (check for interactions)
- Under 18 years of age (unless recommended by pediatrician)
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A few useful answers.
Research & further reading
More category questions
How should I store this supplement?
Store in a cool, dry place away from direct sunlight. Most supplements are stable at room temperature (59-77°F). Keep the bottle sealed between uses. Check the label for any specific storage requirements — some probiotics and oils require refrigeration.
Can I take this with other supplements?
Most supplements can be taken together safely. However, some minerals compete for absorption (zinc and iron, calcium and magnesium) and should be taken at different times of day. If you're taking prescription medications, consult your healthcare provider about potential interactions.
How long should I take this supplement?
Most supplements benefit from consistent daily use over 2-3 months to achieve full effect. Some (like vitamins and minerals) can be taken indefinitely as part of a daily routine. Others (like specific herbs) may benefit from cycling. Follow the product's recommended protocol or consult a practitioner.
When is the best time to take this?
Fat-soluble supplements (vitamins A, D, E, K, omega-3, CoQ10) should be taken with a meal containing fat. Water-soluble supplements (B vitamins, vitamin C) can be taken anytime. Minerals are generally best absorbed with food. Probiotics should be taken with or just before a meal. Check the product label for specific timing recommendations.
How do I know if this supplement is working?
Track your specific health goals — energy levels, sleep quality, joint comfort, digestion, mood, etc. Most supplements take 2-8 weeks for noticeable effects. For objective measurement, baseline lab tests before starting (and repeat at 3 months) provide definitive evidence. The Gabriel Score incorporates clinical evidence for expected outcomes.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.