Omne Diem

Histamine Digest, 120 Capsules

Histamine Digest by Omne Diem is an enzyme-based supplement featuring diamine oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut.

4.3 across 1 sources

May be a fit for

  • Adults seeking diamine oxidase (DAO) enzyme support after histamine-rich meals
  • Those who may help maintain comfort when consuming aged cheeses or fermented foods
  • Individuals supporting histamine breakdown before dining out or drinking wine
$89.99

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CapsulesFormat
120 CapsulesPack size
The essentials

A closer look.

Histamine Digest by Omne Diem is an enzyme-based supplement featuring diamine oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine in the gut. It's designed for individuals who experience discomfort after consuming histamine-rich foods such as aged cheeses, wine, or fermented products, and supports the body's natural histamine metabolism.

Why It's Worth Considering: The formulation centers on DAO supplementation taken before meals, directly targeting the digestive phase where histamine from food is most likely to accumulate for those with reduced enzyme activity.

The Apotheca perspective

50+ signals. A clearer standard.

Our curation and trust scoring bring together manufacturing, testing, research, practitioner insight and reviews from across the web.

82OUT OF 100
Manufacturing8686
Lab verification7070
Transparency6060

Our score is an editorial assessment, not a product certification or a guarantee of results.

Inside the formula

Product details

Who it may suit

May be a fit for

  • Adults seeking diamine oxidase (DAO) enzyme support after histamine-rich meals
  • Those who may help maintain comfort when consuming aged cheeses or fermented foods
  • Individuals supporting histamine breakdown before dining out or drinking wine
  • People seeking DAO activity support for occasional histamine sensitivity

Considerations

  • Known allergy to any ingredient (check label)
  • Currently pregnant or breastfeeding (consult healthcare provider)
  • Taking prescription medications (check for interactions)
  • Under 18 years of age (unless recommended by pediatrician)
From across the web

Real reviews. A wider perspective.

Customer reviews, social conversations and expert insights, with every source in view.

4.3/5Aggregate source rating
Marketplaces & brand websites
Amazon, iHerb and direct brand reviews
Social & community
Reddit, X, Instagram and TikTok
Video & creators
YouTube and creator perspectives

Coverage varies by product and brand.

899 product and brand ratings and mentions across 1 sources.

Good to know

A few useful answers.

Research & further reading

More category questions

How should I store this supplement?

Store in a cool, dry place away from direct sunlight. Most supplements are stable at room temperature (59-77°F). Keep the bottle sealed between uses. Check the label for any specific storage requirements — some probiotics and oils require refrigeration.

Can I take this with other supplements?

Most supplements can be taken together safely. However, some minerals compete for absorption (zinc and iron, calcium and magnesium) and should be taken at different times of day. If you're taking prescription medications, consult your healthcare provider about potential interactions.

How long should I take this supplement?

Most supplements benefit from consistent daily use over 2-3 months to achieve full effect. Some (like vitamins and minerals) can be taken indefinitely as part of a daily routine. Others (like specific herbs) may benefit from cycling. Follow the product's recommended protocol or consult a practitioner.

When is the best time to take this?

Fat-soluble supplements (vitamins A, D, E, K, omega-3, CoQ10) should be taken with a meal containing fat. Water-soluble supplements (B vitamins, vitamin C) can be taken anytime. Minerals are generally best absorbed with food. Probiotics should be taken with or just before a meal. Check the product label for specific timing recommendations.

How do I know if this supplement is working?

Track your specific health goals — energy levels, sleep quality, joint comfort, digestion, mood, etc. Most supplements take 2-8 weeks for noticeable effects. For objective measurement, baseline lab tests before starting (and repeat at 3 months) provide definitive evidence. The Gabriel Score incorporates clinical evidence for expected outcomes.

Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.

Omne Diem - Histamine Digest, 120 Capsules Omne Diem

Apotheca quality score

82/100

The overall score combines several sources of information. The individual dimensions below show where those signals are stronger or more limited; they are not a simple average of the overall score.

Manufacturing8686
Lab verification7070
Review consensus91.491.4
Practitioner signals5050
Community signals5353
Transparency6060
See available brand signals
✓
Third-party lab tested (heavy metals, contaminants)Pass
✓
Good manufacturing practices verifiedStandard
✓
Premium ingredient sourcing with bioavailable formsHigh
✓
Clean FDA regulatory recordNo issues
✓
Positive consumer reviews and community feedbackGood
✓
Authorized distribution channel verifiedDirect

Our score is an editorial assessment, not a product certification or a guarantee of results.

How our scoring works ↗