Pure Encapsulations

PureDefense Collagen w/ Bone Broth

Powder · 400 g

  • Adults seeking collagen peptide support for joint mobility and comfort
  • Individuals maintaining connective tissue integrity through bone broth-derived compounds
  • Practitioners protocols requiring dual-source collagen and bone broth formulas
  • Joint Health · 52% of verified reviews
Quality & Trust Score
86 Strong Evidence
★★★★☆ 4.4 (4.7K) 8 sources
See breakdown →
Manufacturing78
Lab Verification68
Review Consensus95.0
Brand-verified ·Good manufacturing practices verifiedQuality ingredients with verified sourcingClean FDA regulatory recordPositive consumer reviews and community feedbackAuthorized distribution channel verified
Referenced by  A Midwestern Doctor, Dr. Sherri Tenpenny & Dr. Mark Sircus + 7 more →
$58.99
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Ingredients & product label

Serving Size:
2 scoops (approximately 20 grams)

Amount Per Serving:

Calories ... 70
Total Carbohydrate ... 1 g
Protein ... 15 g
Sodium ... 600 mg
EpiCor® dried yeast fermentate complex (from Saccharomyces cerevisiae) ... 250 mg
Turkey tails mushroom (Coriolus versicolor) extract (fruiting body) (certified organic) (standardized to contain 30% beta glucan) ... 100 mg
Mushroom beta glucan (from reishi) (Ganoderma lucidum) extract (mycelia) (standardized to contain 70% beta 1,3/1,6 glucan) ... 100 mg
Aged fermented black garlic (Allium sativum) extract (bulb) (standardized to contain 0.1% S-Allyl Cysteine) ... 100 mg
Turmeric complex ((Curcuma longa) extract (rhizome) and quillaja extract (wood)) (standardized to contain 30% curcuminoids) ... 100 mg
Proprietary vegetable complex ... 100 mg
(containing organic broccoli powder, organic broccoli sprout powder, organic tomato powder, organic carrot powder, organic spinach powder, organic kale powder)

Other Ingredients:
hydrolyzed collagen (from bovine), beef bone broth powder, natural roasted chicken flavor, sunflower lecithin, salt

If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use. Keep out of the reach of children.

Label directions

As a dietary supplement, mix 1 serving into 8 oz. of hot water and stir to dissolve. Consume immediately.

Product label and ingredient information for Pure Encapsulations - PureDefense Collagen w/ Bone Broth Open original label

Source: Fullscript supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.

About Pure Encapsulations - PureDefense Collagen w/ Bone Broth

PureDefense Collagen with Bone Broth from Pure Encapsulations combines hydrolyzed collagen peptides with concentrated bone broth to support connective tissue integrity, joint comfort, and skin structure. Formulated by a practitioner-trusted brand known for rigorous ingredient sourcing and hypoallergenic standards, it's designed for adults seeking a dual-source collagen approach.

Why It's Worth Considering: The combination of hydrolyzed collagen peptides alongside bone broth concentrate provides both targeted peptide fractions and naturally occurring cofactors, offering a more complete matrix than isolated collagen alone.

Compare & Learn
Collagen Types I, II, III

Why Gabriel Recommends This

Quality & Trust Score: 86 Strong Evidence
Quality Verified
Pure Encapsulations products are evaluated across 50+ quality signals including manufacturing standards, lab verification, and ingredient sourcing transparency.
Label details
Ingredient amounts and serving sizes are shown in the product label section when supplier information is available.
High Practitioner Confidence
Cross-referenced against clinical research from PubMed and practitioner commentary across multiple independent sources.
Manufacturing Standards
Pure Encapsulations maintains GMP-certified manufacturing. Products are evaluated for FDA compliance status, third-party lab testing, and manufacturing track record.
Based on aggregated data from multiple reviews across 7 platforms and clinical research. How the Quality & Trust Score works →
Recommendation generated by Gabriel AI based on publicly available practitioner commentary and quality data. Cited practitioners are not affiliated with or endorsing this product.

How to Take

As a dietary supplement, mix 1 serving into 8 oz. of hot water and stir to dissolve. Consume immediately.

Who Benefits

Best For

  • Adults seeking collagen peptide support for joint mobility and comfort
  • Individuals maintaining connective tissue integrity through bone broth-derived compounds
  • Practitioners protocols requiring dual-source collagen and bone broth formulas
  • Those supporting post-exercise recovery with hydrolyzed collagen and bone broth matrix

Cautions

  • Fish/shellfish allergy (if marine collagen)
  • Histamine intolerance (some collagen products trigger histamine)
  • Kidney disease on protein-restricted diet
  • Alpha-gal syndrome (if bovine collagen)

What to Expect

1
Week 2–4
Nail & Hair
Reduced nail brittleness, less breakage
2
Week 4–8
Skin Hydration
Improved skin moisture and elasticity
3
Month 2–3
Joint Comfort
Reduced joint stiffness and pain
4
Month 3–6
Structural Repair
Measurable collagen density improvement
Based on hydrolyzed collagen peptide studies at 10-15g/day. Consistent daily use is key.

Compare Collagen Types

Source and type matter
FeatureType I/III (bovine)Type II (chicken)Marine (fish)Multi-Collagen
Best ForSkin, hair, nails, gutJoints, cartilageSkin (smallest peptides)All-around
SourceGrass-fed cattleChicken sternumWild-caught fishMultiple sources
AbsorptionGoodGoodExcellent (smallest MW)Good
Peptide Size3-6 kDa10-30 kDa1-3 kDaVaries

Frequently Taken Together

Nordic Naturals - Vitamin C Gummies
Collagen Synthesis
Vitamin C
Vitamin C is REQUIRED for collagen synthesis. Without adequate C, supplemental collagen peptides cannot be assembled into new collagen fibers. Essential pairing.
Nordic Naturals - Vitamin C Gummies
$14.99
NutriDyn - Hyaluronic Acid
Skin Hydration
Hyaluronic Acid
Collagen provides structure while hyaluronic acid provides moisture. Together they address both aspects of skin aging.
NutriDyn - Hyaluronic Acid
$47.25
Pure Encapsulations - Biotin Complex Hair & Skin
Hair & Nails
Biotin
Biotin supports keratin production (hair, nails) while collagen provides the structural protein matrix. Comprehensive beauty stack.
Pure Encapsulations - Biotin Complex Hair & Skin
$45.99

Frequently Asked Questions

  • Yes, multiple randomized controlled trials show oral collagen peptides (10-15g/day) significantly improve skin elasticity (+15-20%), reduce wrinkles, strengthen nails, and reduce joint pain over 8-12 weeks. The key is hydrolyzed peptides (not gelatin) which are small enough to be absorbed and signal fibroblasts to produce new collagen.

  • Collagen can be taken anytime. Many people add it to morning coffee or smoothies. For joint benefits, some practitioners recommend taking on an empty stomach. For skin, consistency matters more than timing. Take with vitamin C for optimal synthesis.

  • For skin: 5-10g/day (Verisol studies). For joints: 10-15g/day. For gut healing: 15-20g/day. Most collagen powders provide 10-20g per scoop. Studies consistently show 10g/day as the minimum effective dose for measurable skin improvement.

  • Both are collagen protein, but hydrolyzed collagen peptides are broken into smaller fragments (1-6 kDa) that dissolve in cold water and are absorbed more efficiently. Gelatin is partially hydrolyzed, it forms a gel, doesn't dissolve in cold liquids, and has lower bioavailability. For supplementation, always choose hydrolyzed collagen peptides.

Real Reviews. Real Sources.

4.4
4702 reviews
5 star
55%
4 star
25%
3 star
10%
2 star
6%
1 star
4%
All (4702)
10 Clinical Research
iHerb
0 iHerb
Amazon
4531 Amazon
10 Practitioners
Reddit
45 Reddit
X
30 X
TikTok
30 TikTok
Instagram
22 Instagram
Substack
4 Substack
4.7K ratings aggregated across 8 sources · full-text reviews below
Sort by:
Apotheca's Analysis · 50+ Signals Across 6 Dimensions
Mixed consensus: some users report skin and joint benefits over months, but many see no results and question efficacy vs. marketing claims.
Joint Health
52%
Skin Quality
58%
Long-term Use
61%
Brand Trust
44%
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Compatibility Guide

Works Well With

Vitamin C
Essential for collagen synthesis
Omega-3
Both support skin and joint health

Take Separately From

No significant interactions identified. Always consult your healthcare provider.

Research Behind This

Pure Encapsulations Product Quality Assessment
Quality & Trust Score Analysis
This product has been evaluated across 50+ quality signals including third-party testing, manufacturing standards, ingredient sourcing, and clinical evidence. Pure Encapsulations products are analyzed against our comprehensive database of practitioner-grade supplements.
Practitioner Network Endorsement Data
Apotheca Practitioner Intelligence
Pure Encapsulations is referenced across our practitioner network of clinical recommendations, YouTube health channels, and professional forums. Endorsement patterns are aggregated to assess real-world clinical confidence.

Practitioner Insights

Who This Is For

✓ Great For

Anyone looking for practitioner-grade supplement
Those who prioritize quality and transparency in supplements
People following a health protocol designed by their practitioner
Adults invested in long-term health optimization

⚠ Important Notes

Always consult your healthcare provider before starting any supplement
Check for interactions with current medications
If pregnant or nursing, seek professional guidance first
Compare options using Apotheca's AI to find the best fit for your goals
Pure Encapsulations is part of Gabriel's curated marketplace of practitioner-grade supplement brands. Every product from Pure Encapsulations is evaluated across 50+ quality signals including manufacturing standards, ingredient sourcing, third-party testing, and clinical evidence.
Gabriel VerifiedQuality Analyzed

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Pure Encapsulations
Pure Encapsulations - PureDefense Collagen w/ Bone Broth
86
Strong Evidence
Quality & Trust Score
Strong quality signals. Meets recommended thresholds across most pillars.
Last updated: September 08, 2026
Score Breakdown
Manufacturing & GMP
78
Lab Verification
68
Review Consensus
95.0
Practitioner Confidence
52.0
Community & Social
71
Transparency
58
Consumer & Practitioner Intelligence
★★★★☆ 4.4 from 4702 reviews across 8 sources
Clinical Research 30Practitioner Data 10Amazon 4531Community 131+
Aggregated from verified purchases, practitioner clinical notes, and real-world outcome data
Scored across 50+ quality dimensions from 15+ independent databases. No brand can pay to influence their score. No sponsored rankings. Ever.
See how this product scores against your health profile · How the Quality & Trust Score works