Advanced Digestive Enzymes (formerly Bio-Gest), 180 Capsules
Size: 180 capsules
May be a fit for
- Adults seeking enzyme and betaine HCl support for protein breakdown
- Individuals supporting fat digestion with ox bile and lipase
- Those noticing occasional bloating after high-protein or fatty meals
Save together with Wellness Circles
Invite friends or family to a Wellness Circle. Your group can unlock savings together. See current tiers and terms before joining.
Explore Wellness CirclesA closer look.
Advanced Digestive Enzymes from Thorne is a comprehensive digestive support formula combining betaine HCl, pepsin, pancreatin, and ox bile extract to support the full breakdown of proteins, fats, and carbohydrates. Formerly sold as Bio-Gest, this capsule formulation is designed for adults who experience occasional digestive discomfort or those with lower gastric acid output who want broader digestive coverage.
Why It's Worth Considering: Thorne's practitioner-grade manufacturing standards and the combination of both upper and lower GI enzymes in a single capsule make this a well-rounded option compared to single-enzyme products.
50+ signals. A clearer standard.
Our curation and trust scoring bring together manufacturing, testing, research, practitioner insight and reviews from across the web.
Our score is an editorial assessment, not a product certification or a guarantee of results.
Thorne · 180 CapsulesMake it part of your routine.
Take 1-2 capsules with each meal or as recommended by your health professional.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size:
Two Capsules
Amount Per Serving:
Betaine Hydrochloride ... 480 mg
L-Glutamic Acid Hydrochloride ... 480 mg
Pancreatin (Porcine)† ... 140 mg
Ox Bile concentrate ... 80 mg
Pepsin (Porcine) ... 70 mg
Other Ingredients:
Hypromellose (derived from cellulose), Leucine, Silicon Dioxide.
Gluten Free
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health professional before using this product.
INTERACTIONS
Bio-Gest should not be used concurrent with H2-blocking drugs and proton pump inhibitors because these drugs are intended to block the production of stomach HCl
ADDITIONAL WARNINGS
Bio-Gest is contraindicated in patients with peptic ulcers. It is not recommended to remove the Bio-Gest powder from the capsule to take orally, as it can be irritating to the oral mucosa.
Label directions
Take 1-2 capsules with each meal or as recommended by your health professional.
Open original label ↗
Source: authorized supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking enzyme and betaine HCl support for protein breakdown
- Individuals supporting fat digestion with ox bile and lipase
- Those noticing occasional bloating after high-protein or fatty meals
- Practitioner protocols requiring multi-enzyme coverage including protease and amylase
Considerations
- Active stomach or duodenal ulcers (especially betaine HCl)
- Taking blood thinners (some enzymes have mild anti-platelet activity)
- Active pancreatitis
Explore complementary products
Metabolic Maintenance - BioMaintenance™ Prebiotic + Fiber, 378 gReal reviews. A wider perspective.
Customer reviews, social conversations and expert insights, with every source in view.
- Marketplaces & brand websites
- Amazon, iHerb and direct brand reviews
- Social & community
- Reddit, X, Instagram and TikTok
- Video & creators
- YouTube and creator perspectives
Coverage varies by product and brand.
4650 product and brand ratings and mentions across 7 sources.
These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
Explore the source sentiment summary
Overwhelmingly negative sentiment driven by PE acquisition, fired R&D team, counterfeit products, and refusal to share COAs; formula itself gets niche praise.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
When should I take digestive enzymes?
Take immediately before or with the first bites of your meal. Enzymes need to be in the stomach when food arrives. Taking them after eating is less effective. For best results, take with every substantial meal — especially meals high in fat, protein, or hard-to-digest foods.
Do I need enzymes if I take probiotics?
They serve different functions. Enzymes physically break down food into absorbable nutrients. Probiotics are living bacteria that optimize the gut microbiome, produce vitamins, and support immune function. Many gut issues benefit from both — especially after age 40 when natural enzyme production declines.
Can I become dependent on digestive enzymes?
No. Digestive enzymes do not cause your body to produce fewer of its own enzymes. They supplement what your body is already making (or under-making). You can stop taking them anytime without withdrawal or rebound. If your symptoms return after stopping, it means you still need the support — not that you've become dependent.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.