Advanced Iron Complex (formerly Ferrasorb), 60 Capsules
Size: 60 capsules
May be a fit for
- Adults with low ferritin seeking highly absorbable iron bisglycinate chelate
- Women of childbearing age looking to maintain healthy iron stores
- Practitioners supporting patients with diet-related iron insufficiency
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Thorne's Advanced Iron Complex (formerly Ferrasorb) delivers iron bisglycinate chelate, a highly bioavailable, stomach-friendly form of iron, alongside folate (as 5-MTHF), vitamin B12, and vitamin C to support red blood cell formation and healthy iron status. Formulated for individuals with increased iron needs, including menstruating women, athletes, or those managing dietary gaps.
Why It's Worth Considering: The iron bisglycinate chelate form is gentler on the GI tract than ferrous sulfate, and pairing it with 5-MTHF and active B12 addresses the full nutritional picture for iron-deficiency-related fatigue support.
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Thorne · 60 CapsulesMake it part of your routine.
Take 1 capsule one to three times daily or as recommended by your health professional.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size:
One Capsule
Amount Per Serving:
Vitamin C (as Ascorbic Acid) ... 15 mg
Vitamin B6 (as Pyridoxal 5’-Phosphate) ... 5 mg
Folate (400 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) ... 667 mcg DFE
Vitamin B12 (as Methylcobalamin) ... 300 mcg
Iron (as Ferrochel® Ferrous Bisglycinate Chelate)†† ... 36 mg
Other Ingredients:
Hypromellose (derived from cellulose) capsule, Microcrystalline Cellulose, Leucine, Silicon Dioxide.
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health professional before using this product.
INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
ADDITIONAL WARNINGS
Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under six. Keep this product out of reach of children. In case of accidental overdose, call a doctor or poison control center immediately.
Label directions
Take 1 capsule one to three times daily or as recommended by your health professional.
Open original label ↗
Source: authorized supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults with low ferritin seeking highly absorbable iron bisglycinate chelate
- Women of childbearing age looking to maintain healthy iron stores
- Practitioners supporting patients with diet-related iron insufficiency
- Individuals who experience GI discomfort with standard iron supplements
Considerations
- Hemochromatosis (iron overload disorder)
- Taking thyroid medication — separate by 4+ hours
- Active GI bleeding (need medical evaluation, not supplements)
- Thalassemia or other iron-loading anemias
Compatibility & interactions
Works Well With
Take Separately From
What to expect over time
Energy Improvement
Reduced fatigue as oxygen delivery improves
Hemoglobin Rise
Measurable Hb increase (1-2 g/dL)
Ferritin Repletion
Ferritin stores rebuilding
Full Repletion
Target ferritin 50-100 ng/mL
Based on clinical iron supplementation data. Continue supplementing until ferritin reaches 50+ ng/mL.
Compare the options
Compare Iron Forms
Absorption and tolerability matter
| Feature | Bisglycinate (gentle) | Ferrous Sulfate | Ferrous Fumarate | Heme Iron |
|---|---|---|---|---|
| Absorption | High (chelated) | Moderate | Moderate | Highest (animal-derived) |
| GI Side Effects | Minimal | Common (constipation) | Moderate | Minimal |
| Best For | Sensitive stomachs | Budget, proven | Higher elemental iron | Maximum absorption |
| Take With | Empty stomach OK | Vitamin C required | Vitamin C helps | Anytime |
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Pure Encapsulations - B12 Folate, 60 CapsulesReal reviews. A wider perspective.
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14839 product and brand ratings and mentions across 8 sources.
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Explore the source sentiment summary
Iron supplementation praised for fatigue and anxiety relief, but Thorne brand trust is undermined by PE acquisition fears, CoA transparency issues, and counterfeit concerns.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
What is the best form of iron supplement?
Iron bisglycinate (Ferrochel) is the best-tolerated form with high absorption and minimal GI side effects. Ferrous sulfate is the most studied but commonly causes constipation and nausea. Heme iron polypeptide has the highest absorption rate but is animal-derived.
Why does iron cause constipation?
Non-chelated iron forms (ferrous sulfate, fumarate) are poorly absorbed — the unabsorbed iron irritates the gut lining and slows peristalsis. Chelated forms (bisglycinate) are absorbed more completely, leaving less unabsorbed iron in the gut. Taking vitamin C improves absorption and reduces GI side effects.
Can I take iron with other supplements?
Separate iron from calcium, zinc, magnesium, and dairy by 2+ hours (they compete for absorption). Separate from thyroid medication by 4+ hours. DO take iron WITH vitamin C (doubles absorption). Avoid taking with coffee or tea (tannins reduce absorption by 60%).
How do I know if I need iron?
Get a complete iron panel: serum ferritin (most sensitive — optimal is 50-100 ng/mL), serum iron, TIBC, and transferrin saturation. Symptoms of deficiency: fatigue, cold hands/feet, pale skin, brittle nails, shortness of breath, brain fog, and restless legs. Ferritin below 30 ng/mL warrants supplementation in most cases.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.