Capsules · 60 capsules
Serving Size:
Two Capsules
Amount Per Serving:
Berberine HCl (from Indian Barberry extract) (root) (Berberis aristata) ... 450 mg
Berberine Phytosome† (Berberis aristata extract (root) / Phospholipid complex from Pea, Sunflower, Grape Seed) ... 550 mg
Other Ingredients:
Hypromellose (derived from cellulose) capsule, calcium laurate.
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY WARNING
If pregnant, nursing, or trying to conceive, do not use this product.
INTERACTIONS
Has been shown to decrease the activity of the cytochrome p450 (CYP) enzymes CYP2D6, CYP2C9, and CYP3A4.
Individuals with a known, serious allergy to peanuts may occasionally react to other legumes, including peas. This product contains pea protein. If you have a known, serious peanut allergy, it is recommended to use this product with caution.
Take 1-2 capsules two times daily with food or as recommended by your health-care practitioner.
Open original label
Source: Fullscript supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Thorne's Berberine delivers berberine HCl, an alkaloid compound found in plants like barberry and goldenseal, in capsule form to support healthy blood sugar metabolism, lipid balance, and gut microbiome health. Formulated by Thorne, a practitioner-trusted brand with rigorous manufacturing standards, it's well-suited for individuals focused on metabolic wellness.
Why It's Worth Considering: Thorne's commitment to manufacturing purity and third-party testing makes this a reliable choice for those who prioritize ingredient integrity in berberine supplementation.
Take 1-2 capsules two times daily with food or as recommended by your health-care practitioner.
Head-to-head clinical trials show berberine 500mg 3x/day produces comparable HbA1c reduction (0.5-0.9%) and fasting glucose reduction to metformin 500mg 3x/day. Berberine also reduces LDL cholesterol and triglycerides, an effect metformin doesn't have. However, berberine is a supplement, not a drug, and should not replace prescribed medication without physician guidance.
Take 500mg 2-3 times daily with meals. The key is splitting the dose, berberine has a short half-life (~5 hours) and taking it with each meal maximizes the post-meal blood sugar benefit. Start with 500mg once daily and increase over 2 weeks to reduce GI side effects (which are similar to metformin).
Common: GI discomfort, diarrhea, constipation, gas (similar to metformin, usually resolves in 1-2 weeks). Berberine can lower blood sugar significantly, monitor if diabetic. It also inhibits CYP3A4 liver enzyme, which affects metabolism of many drugs (statins, blood thinners, antidepressants). Check drug interactions carefully.
Most studies are 3-6 months. Some practitioners recommend cycling: 8 weeks on, 4 weeks off, to maintain effectiveness and allow the gut microbiome to rebalance (berberine has antimicrobial properties). Long-term continuous use appears safe in studies up to 2 years, but cycling is a reasonable precaution.
Apotheca is analyzing ingredient interactions, stacking compatibility, and timing recommendations for Thorne - Berberine. This data will be available soon.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
