SBO Probiotic 50 billion CFU, 60 Capsules
60 Capsules
May be a fit for
- Adults seeking soil-based organism probiotics for digestive balance support
- Those looking to maintain gut flora with 50 billion CFU daily
- Individuals supporting microbiome resilience with spore-forming SBO strains
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Amen SBO Probiotic delivers 50 billion CFU of soil-based organisms (SBOs) per capsule, a distinct class of probiotics naturally adapted to survive harsh digestive conditions without refrigeration. SBO strains are selected for their resilience and may help support gut microbiome balance, digestive comfort, and immune function. Well-suited for adults who haven't responded to conventional lactobacillus-based probiotics or who want a more shelf-stable option.
Why It's Worth Considering: Soil-based organisms form protective endospores, giving them a survival advantage through the GI tract that many standard strains lack, no cold chain required.
50+ signals. A clearer standard.
Our curation and trust scoring bring together manufacturing, testing, research, practitioner insight and reviews from across the web.
Our score is an editorial assessment, not a product certification or a guarantee of results.
Amen · 60 CapsulesMake it part of your routine.
Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
Important cautions & interactions
Product details
Supplement facts & complete label
Serving Size:
2 Vegetable Capsule
Amount Per Serving:
Prebiotic Blend … 440 mg
Fermented Astragalus (Astragalus propinquus; Root)†
Fermented Jerusalem Artichoke (Whole Plant; Helianthus tuberosus)†
Fermented Acacia Fiber†
Fermented Turkey Tail Mushroom (Fruiting Bodies; Trametes versicolor)†
Fermented Holy Basil Leaf (Ocimum tenuiflorum)†
Fermented Sprouted Broccoli Seed†
Probiotic Blend (50B CFU‡) … 143 mg
L. plantarum
L. paracasei
B. subtilis
B. clausii
B. coagulans
S. boulardii
Other Ingredients:
Methylcellulose Capsule
Label directions
Take 2 capsules daily with 8 ounces of water or your favorite beverage. May be taken with or without food.
Label cautions
Do not exceed recommended dose. Pregnant or nursing mothers, children under 18 and individuals with a known medical condition should consult a physician before using this or any dietary supplement. Please use caution if you have allergies or sensitivities to any of the listed ingredients.
Source: authorized supplier original manufacturer label · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking soil-based organism probiotics for digestive balance support
- Those looking to maintain gut flora with 50 billion CFU daily
- Individuals supporting microbiome resilience with spore-forming SBO strains
- People wanting shelf-stable SBO probiotics without refrigeration requirements
Considerations
- Severely immunocompromised (consult physician)
- Active pancreatitis
- Central venous catheters (risk of translocation)
- SIBO (some probiotics may worsen — consult practitioner)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Colonization Begins
Beneficial bacteria begin establishing colonies
GI Improvement
Reduced bloating, improved regularity
Immune Modulation
Enhanced immune markers, fewer infections
Microbiome Shift
Sustained diversity improvement
Based on clinical probiotic research. Initial die-off symptoms (temporary bloating) may occur in the first week.
Compare the options
Compare Probiotic Types
Which strain type is right for you?
| Feature | Multi-Strain (this) | Spore-Based | Saccharomyces | Single-Strain |
|---|---|---|---|---|
| Survivability | Moderate (refrigerate) | Excellent (shelf-stable) | Excellent (yeast-based) | Moderate |
| Best For | General gut health | Antibiotic recovery | Diarrhea, C. diff | Targeted conditions |
| CFU Range | 10-100 billion | 2-5 billion (potent) | 5-10 billion | 1-50 billion |
| Research | Extensive | Growing | Strong (S. boulardii) | Strain-specific |
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Customer reviews, social conversations and expert insights, with every source in view.
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Coverage varies by product and brand.
434 product and brand ratings and mentions across 8 sources.
These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
Explore the source sentiment summary
Mixed sentiment with notable mood and skin benefits reported, but some users experienced side effects like dizziness and nausea with no digestive improvement.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
How many CFU do I need in a probiotic?
For general health maintenance, 10-20 billion CFU is sufficient. For therapeutic use (post-antibiotics, IBS, immune support), 50-100 billion CFU is recommended. More important than CFU count is strain diversity and survivability — a 5 billion spore-based probiotic may be more effective than a 100 billion conventional strain that doesn't survive stomach acid.
Should I take probiotics with food or on an empty stomach?
Take with food or within 30 minutes of eating. Food buffers stomach acid and increases probiotic survival by up to 100x. A small amount of fat in the meal further improves survival. Exception: spore-based probiotics (Bacillus strains) are acid-resistant and can be taken anytime.
Can probiotics cause bloating at first?
Yes — temporary bloating, gas, or changes in bowel habits during the first 3-7 days is common and actually a positive sign. This 'die-off' reaction occurs as beneficial bacteria displace harmful organisms. If symptoms persist beyond 2 weeks, reduce the dose by half and gradually increase.
Do I need to refrigerate probiotics?
It depends on the strain. Most Lactobacillus and Bifidobacterium strains require refrigeration for viability. Spore-based probiotics (Bacillus) and Saccharomyces boulardii are shelf-stable. Check the label — if it says 'viable at time of manufacture' rather than 'at time of expiration,' refrigerate.
Can I take probiotics with antibiotics?
Yes — in fact, it's strongly recommended. Take the probiotic 2-3 hours apart from the antibiotic dose (so the antibiotic doesn't kill the probiotic). Saccharomyces boulardii is particularly resistant to antibiotics. Continue probiotics for at least 2-4 weeks after completing the antibiotic course.
How long should I take probiotics?
For acute use (post-antibiotics, traveler's diarrhea), 4-8 weeks minimum. For chronic conditions (IBS, immune support), ongoing daily use is recommended. Probiotics don't permanently colonize — they exert benefits while you take them and for a limited time after stopping. Think of them as a daily maintenance supplement, not a one-time fix.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.