P-5-P 30mg, 250 Capsules
Klaire Labs P-5-P 30mg delivers pyridoxal-5-phosphate, the biologically active coenzyme form of vitamin B6 that the body can use directly without hepatic conversion.
May be a fit for
- Adults seeking activated B6 without requiring hepatic conversion
- Individuals supporting neurotransmitter synthesis with pyridoxal-5-phosphate
- Practitioners protocols requiring coenzyme-form B6 for sensitive patients
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Klaire Labs P-5-P 30mg delivers pyridoxal-5-phosphate, the biologically active coenzyme form of vitamin B6 that the body can use directly without hepatic conversion. Unlike standard pyridoxine, P-5-P supports neurotransmitter synthesis, amino acid metabolism, and healthy homocysteine levels, particularly relevant for individuals with impaired B6 metabolism or those on medications that deplete conventional B6.
Why It's Worth Considering: Klaire Labs, a practitioner-grade brand, formulates this at a clinically relevant 30mg dose in the active coenzyme form, which may be especially beneficial for those with compromised conversion pathways.
Klaire Labs/SFI Health · 250 CapsulesMake it part of your routine.
Adults take 1 capsule daily with food, or as directed by a healthcare professional. Children: as directed by a healthcare professional.
Important cautions & interactions
Product details
Supplement facts & complete label
Supplement Facts — Serving size: 1 capsule. Servings per container: 250.
Vitamin B6 (as pyridoxal 5'-phosphate): 30 mg (1,765% DV).
Other ingredients: microcrystalline cellulose, vegetarian capsule (hydroxypropyl methylcellulose, water), L-leucine.
Label directions
Adults take 1 capsule daily with food, or as directed by a healthcare professional. Children: as directed by a healthcare professional.
Label cautions
Consult your physician if you are pregnant or nursing, have any medical condition, take prescription drugs, or are under 18. Keep out of reach of children. Store in a cool, dry place (59°F to 85°F) away from direct light.
Source: SFI Health/Klaire Labs manufacturer page and technical data sheet · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking activated B6 without requiring hepatic conversion
- Individuals supporting neurotransmitter synthesis with pyridoxal-5-phosphate
- Practitioners protocols requiring coenzyme-form B6 for sensitive patients
- Those with impaired B6 metabolism needing pre-converted P-5-P
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.