Capsules · 250 capsules · 250 servings · $0.22/serving
Supplement Facts — Serving size: 1 capsule. Servings per container: 250.
Vitamin B6 (as pyridoxal 5'-phosphate): 30 mg (1,765% DV).
Other ingredients: microcrystalline cellulose, vegetarian capsule (hydroxypropyl methylcellulose, water), L-leucine.
Adults take 1 capsule daily with food, or as directed by a healthcare professional. Children: as directed by a healthcare professional.
Consult your physician if you are pregnant or nursing, have any medical condition, take prescription drugs, or are under 18. Keep out of reach of children. Store in a cool, dry place (59°F to 85°F) away from direct light.
Source: SFI Health/Klaire Labs manufacturer page and technical data sheet · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Klaire Labs P-5-P 30mg delivers pyridoxal-5-phosphate, the biologically active coenzyme form of vitamin B6 that the body can use directly without hepatic conversion. Unlike standard pyridoxine, P-5-P supports neurotransmitter synthesis, amino acid metabolism, and healthy homocysteine levels, particularly relevant for individuals with impaired B6 metabolism or those on medications that deplete conventional B6.
Why It's Worth Considering: Klaire Labs, a practitioner-grade brand, formulates this at a clinically relevant 30mg dose in the active coenzyme form, which may be especially beneficial for those with compromised conversion pathways.
Adults take 1 capsule daily with food, or as directed by a healthcare professional. Children: as directed by a healthcare professional.
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
Methylated B vitamins are in their active, bioavailable form, your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Yes, B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Apotheca is analyzing ingredient interactions, stacking compatibility, and timing recommendations for Klaire Labs/SFI Health - P-5-P 30mg. This data will be available soon.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
