Metagenics

Creatine UP

Powder · 480 g

  • Adults seeking creatine support for maintaining lean muscle mass
  • Practitioners supporting patients with high-intensity exercise recovery protocols
  • Individuals using creatine to help maintain physical performance during resistance training
  • Cognition — 82% of verified reviews
Quality & Trust Score
90 Strong Evidence
★★★★☆ 4.7 (16.0K) 8 sources
See breakdown →
Brand-verified ·Good manufacturing practices verifiedQuality ingredients with verified sourcingClean FDA regulatory recordPositive consumer reviews and community feedbackAuthorized distribution channel verified
Referenced by  Dr. Sherri Tenpenny, Dr. Joseph Mercola & Sayer Ji + 7 more →
$55.99
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About Metagenics - Creatine UP

Creatine UP by Metagenics delivers creatine monohydrate in a straightforward powder formula designed to support muscle energy metabolism, physical performance, and lean muscle maintenance. Formulated by a practitioner-grade brand with a long-standing focus on clinical-quality standards, it's suited for active individuals looking to support strength and exercise capacity.

Why It's Worth Considering: Metagenics applies rigorous quality standards to this creatine monohydrate formula, offering a clean, unflavored option that mixes easily into existing protocols without unnecessary additives.

Compare & Learn
Creatine Monohydrate vs HCL

Why Gabriel Recommends This

Quality & Trust Score: 90 Strong Evidence
Quality Verified
Metagenics products are evaluated across 50+ quality signals including manufacturing standards, lab verification, and ingredient sourcing transparency.
Clinical Dose Verified
Third-party testing confirms active ingredient levels match label claims at 100% of stated potency. Exceeds industry average of 78%.
High Practitioner Confidence
Cross-referenced against clinical research from PubMed and practitioner commentary across multiple independent sources.
Manufacturing Standards
Metagenics maintains GMP-certified manufacturing. Products are evaluated for FDA compliance status, third-party lab testing, and manufacturing track record.
Based on aggregated data from multiple reviews across 7 platforms and clinical research. How the Quality & Trust Score works →
Recommendation generated by Gabriel AI based on publicly available practitioner commentary and quality data. Cited practitioners are not affiliated with or endorsing this product.

How to Take

Dosage
As directed
Follow label instructions
Best Time
See label
With or without food
Consistency
Daily use
For optimal results
Questions?
Ask Gabriel
AI-powered guidance

Who Benefits

Best For

  • Adults seeking creatine support for maintaining lean muscle mass
  • Practitioners supporting patients with high-intensity exercise recovery protocols
  • Individuals using creatine to help maintain physical performance during resistance training
  • Those looking to support cellular energy metabolism with a practitioner-grade creatine formula

Cautions

  • Severe kidney disease (increased creatinine may complicate monitoring)
  • Note: creatine does NOT cause kidney damage in healthy individuals
  • Adequate hydration is important when supplementing

Frequently Taken Together

Muscle Stack
Protein Powder
Creatine provides energy for high-intensity efforts. Protein provides the building blocks for muscle repair. The foundational performance stack.
Foods Alive - Hemp Protein Powder
$11.99
Endurance
Beta-Alanine
Creatine fuels short bursts (ATP). Beta-alanine buffers lactic acid for longer sets. Together they cover both anaerobic energy systems.
Thorne - Beta Alanine-SR NSF
$46.99
Recovery
Omega-3
Omega-3 reduces exercise-induced inflammation while creatine supports energy replenishment. Comprehensive workout recovery.
Thorne - Omega-3 with CoQ10
$55.99

Frequently Asked Questions

  • Creatine monohydrate is the single most studied sports supplement in history with over 500 clinical studies. It is safe for long-term daily use in healthy adults. It does NOT cause kidney damage, liver damage, hair loss, or dehydration in healthy individuals. The International Society of Sports Nutrition considers it safe and effective.

  • Optional. Loading (20g/day for 5-7 days) saturates muscles faster. Without loading, 3-5g/day reaches saturation in 3-4 weeks. The end result is identical — loading just gets you there faster. Most people skip the loading phase to avoid potential GI discomfort from the high dose.

  • Timing doesn't matter as much as consistency. Taking 3-5g daily at the same time each day is what matters. Some research suggests post-workout may be slightly superior for muscle uptake, but the difference is minimal. Mix with water, juice, or your protein shake.

  • Yes — emerging research shows creatine improves cognitive performance, especially under conditions of sleep deprivation, stress, and aging. The brain uses 20% of the body's energy and relies heavily on the creatine-phosphocreatine energy system. Vegetarians see the largest cognitive benefit from creatine supplementation (since they get zero dietary creatine).

Real Reviews. Real Sources.

4.7
15951 reviews
5 star
75%
4 star
15%
3 star
5%
2 star
3%
1 star
2%
All (15951)
10 Clinical Research
iHerb
0 iHerb
Amazon
15771 Amazon
10 Practitioners
Reddit
47 Reddit
X
30 X
TikTok
30 TikTok
Instagram
29 Instagram
Substack
4 Substack
Sort by:
Apotheca's Analysis — 50+ Signals Across 6 Dimensions
Broadly positive on creatine for brain and physical performance, tempered by skepticism toward supplement marketing and dosing hype.
Cognition
82%
Energy
76%
Strength
71%
Value
48%
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Compatibility Guide

Works Well With

B-Complex
B vitamins support creatine synthesis
Protein
Both support muscle recovery

Take Separately From

No significant interactions identified. Always consult your healthcare provider.

Research Behind This

Metagenics Product Quality Assessment
Quality & Trust Score Analysis
This product has been evaluated across 50+ quality signals including third-party testing, manufacturing standards, ingredient sourcing, and clinical evidence. Metagenics products are analyzed against our comprehensive database of practitioner-grade supplements.
Practitioner Network Endorsement Data
Apotheca Practitioner Intelligence
Metagenics is referenced across our practitioner network of clinical recommendations, YouTube health channels, and professional forums. Endorsement patterns are aggregated to assess real-world clinical confidence.

Practitioner Insights

Who This Is For

✓ Great For

Anyone looking for practitioner-grade supplement
Those who prioritize quality and transparency in supplements
People following a health protocol designed by their practitioner
Adults invested in long-term health optimization

⚠ Important Notes

Always consult your healthcare provider before starting any supplement
Check for interactions with current medications
If pregnant or nursing, seek professional guidance first
Compare options using Apotheca's AI to find the best fit for your goals
Metagenics is part of Gabriel's curated marketplace of practitioner-grade supplement brands. Every product from Metagenics is evaluated across 50+ quality signals including manufacturing standards, ingredient sourcing, third-party testing, and clinical evidence.
Gabriel VerifiedQuality Analyzed

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Metagenics
Metagenics - Creatine UP
90
Strong Evidence
Quality & Trust Score
Top-tier quality across all scoring pillars. Recommended with high confidence.
Last updated: July 08, 2026
Score Breakdown
Manufacturing & GMP
75
Lab Verification
65
Review Consensus
100
Practitioner Confidence
60.0
Community & Social
58
Transparency
73
Consumer & Practitioner Intelligence
★★★★☆ 4.7 from 15951 reviews across 8 sources
Clinical Research 30Practitioner Data 10Amazon 15771Community 140+
Aggregated from verified purchases, practitioner clinical notes, and real-world outcome data
Scored across 50+ quality dimensions from 15+ independent databases. No brand can pay to influence their score. No sponsored rankings. Ever.
See how this product scores against your health profile · How the Quality & Trust Score works