Vitamin D3 with K2
Practitioner-grade vitamin d3 with k2 by Ortho Molecular Products
May be a fit for
- Adults seeking D3 and K2 for bone matrix and calcium utilization support
- Practitioners protocols requiring combined cholecalciferol and menaquinone in one formula
- Individuals with limited sun exposure needing clinically dosed vitamin D3 repletion
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Ortho Molecular Products' Vitamin D3 with K2 pairs cholecalciferol (D3) with menaquinone-7 (MK-7), the long-acting form of vitamin K2, to support calcium metabolism, bone density, and cardiovascular health. This combination is formulated for individuals seeking synergistic support for skeletal integrity and soft-tissue calcium distribution.
Why It's Worth Considering: Ortho Molecular is a practitioner-trusted brand known for tightly controlled manufacturing standards; pairing D3 with MK-7 specifically addresses the concern that high-dose D3 supplementation should be balanced with K2 to support proper calcium utilization.
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Ortho Molecular ProductsMake it part of your routine.
1 drop (0.025 mL) per day or as recommended by your health care professional. Can be taken directly on the tongue and swallowed or mixed with the beverage of your choice.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size:
1 Drop (0.025 mL)
Amount Per Serving:
Vitamin D (D3 as Cholecalciferol) ... 25 mcg (1,000 IU)
Vitamin K2 (as Menaquinone-7 (MK-7)) (MenaQ7®PRO) ... 10 mcg
Other Ingredients:
Medium Chain Triglycerides.
Does Not Contain: Gluten, corn, yeast, artificial colors or flavors
DO NOT ACCEPT IF LABEL SHOWS SIGNS OF TAMPERING
WARNING: all forms of Vitamin K may interact with blood thinning medications. If you are taking such medications, please consult your physician before taking this product.
As with all dietary supplements, some individuals may not tolerate or may be allergic to the ingredients used. Please read the ingredient panel carefully prior to ingestion. Cease taking this product and consult your physician if you have negative reactions upon ingestion.
KEEP CONTAINER TIGHTLY CLOSED. STORE AT ROOM TEMPERATURE. KEEP OUT OF REACH OF CHILDREN.
This product was sealed for your protection. Do not use if outer logoed neck seal is missing or damaged.
Label directions
1 drop (0.025 mL) per day or as recommended by your health care professional. Can be taken directly on the tongue and swallowed or mixed with the beverage of your choice.
Source: authorized supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking D3 and K2 for bone matrix and calcium utilization support
- Practitioners protocols requiring combined cholecalciferol and menaquinone in one formula
- Individuals with limited sun exposure needing clinically dosed vitamin D3 repletion
- Those supporting cardiovascular tissue health through K2-directed calcium metabolism
Considerations
- Hypercalcemia (elevated blood calcium)
- Sarcoidosis or other granulomatous diseases
- Severe kidney disease without medical supervision
- Taking thiazide diuretics (monitor calcium)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Serum Levels Rise
Measurable increase in 25(OH)D
Immune Support
Improved innate immune function
Mood & Energy
Reduced fatigue and improved mood
Optimal Range
Target 50-80 ng/mL achieved
Based on clinical studies on vitamin D3 supplementation. Response varies by baseline levels, body weight, and skin tone.
Compare the options
Compare Vitamin D Forms
D3 vs D2 vs D3+K2
| Feature | D3 (Cholecalciferol) | D2 (Ergocalciferol) | D3 + K2 Combo |
|---|---|---|---|
| Source | Animal (lanolin/lichen) | Plant/fungal | Animal + bacterial |
| Potency | 87% more effective at raising serum D | Baseline | Same as D3 + K2 synergy |
| Half-Life | ~2-3 weeks | ~2-3 days | ~2-3 weeks |
| Best For | General supplementation | Vegan-only option | Bone + cardiovascular health |
| Evidence | Strong (gold standard) | Moderate | Strong (synergistic) |
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More category questions
How much vitamin D3 should I take daily?
Most functional medicine practitioners recommend 5,000 IU daily for adults with normal BMI, and up to 10,000 IU for those with obesity or severe deficiency. The Endocrine Society recommends maintaining serum 25(OH)D levels between 40-60 ng/mL. Test your levels every 3-6 months.
Is vitamin D3 better than D2?
Yes. D3 (cholecalciferol) is 87% more effective at raising and maintaining serum vitamin D levels compared to D2 (ergocalciferol). D3 also has a longer half-life. D2 is only preferred by strict vegans who cannot use lanolin-sourced D3 — lichen-based D3 is the vegan alternative.
Should I take vitamin D3 with vitamin K2?
Yes, especially at doses above 2,000 IU. Vitamin D3 increases calcium absorption from food. Without K2, that calcium can deposit in arteries instead of bones. K2 (MK-7 form) activates osteocalcin (puts calcium in bones) and matrix GLA protein (keeps calcium out of arteries).
Can I take too much vitamin D?
Toxicity is rare below 10,000 IU/day in healthy adults but possible with chronic high-dose use without monitoring. Symptoms of excess include hypercalcemia (nausea, kidney stones, confusion). Always pair high-dose D3 with K2 and test 25(OH)D levels every 3-6 months.
When is the best time to take vitamin D3?
Take with your largest meal containing fat — D3 is fat-soluble and absorption increases 30-50% when taken with dietary fat. Morning or afternoon is preferred over evening, as some studies suggest late-night D3 may interfere with melatonin production.
How long does it take for vitamin D levels to increase?
Serum 25(OH)D typically rises within 1-2 weeks of supplementation. Reaching optimal range (50-80 ng/mL) takes 2-3 months at 5,000 IU/day from a deficient baseline. Higher loading doses (10,000 IU for 8 weeks then maintenance) can accelerate this.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.