Probiotic 123
Probiotic 123 by Pure Encapsulations is a targeted three-strain probiotic formula delivering Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus rhamnosus to support a balanced intestinal microbiome.
May be a fit for
- Clinicians seeking a three-strain probiotic protocol for sensitive patients
- Adults supporting gut microflora balance with a simplified probiotic formula
- Individuals with digestive discomfort seeking Lactobacillus and Bifidobacterium support
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Probiotic 123 by Pure Encapsulations is a targeted three-strain probiotic formula delivering Lactobacillus acidophilus, Bifidobacterium longum, and Lactobacillus rhamnosus to support a balanced intestinal microbiome. Formulated for adults seeking foundational digestive and immune support, it provides a clinically relevant CFU count in a hypoallergenic, encapsulated delivery system free from common excipients.
Why It's Worth Considering: Pure Encapsulations is a practitioner-grade brand known for rigorous raw material testing and minimal-additive formulations, this product reflects that same standard, with strains selected for intestinal resilience and stability.
Pure EncapsulationsMake it part of your routine.
As a dietary supplement, children ages 1-3, take 1/2 scoop daily. Adults and children ages 4 and up, take 1 scoop daily, or as directed by a health professional. Mix with applesauce or yogurt.
Read the complete labelProduct details
Supplement facts & complete label
Supplement Facts. Serving sizes: 1/2 scoop (approximately 0.18 g) or 1 scoop (approximately 0.37 g). Servings per container: 333 half-scoops or 162 full scoops. Probiotic blend: 1.5 billion CFU per half-scoop, 3 billion CFU per full scoop, providing Lactobacillus acidophilus (La-14), Lactobacillus rhamnosus GG, Bifidobacterium lactis (Bl-04), and Bifidobacterium bifidum (Bb-06). Daily Value not established. Other ingredients: hypoallergenic plant fiber (cellulose).
Label directions
As a dietary supplement, children ages 1-3, take 1/2 scoop daily. Adults and children ages 4 and up, take 1 scoop daily, or as directed by a health professional. Mix with applesauce or yogurt.
Source: Original manufacturer package label in authorized supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Clinicians seeking a three-strain probiotic protocol for sensitive patients
- Adults supporting gut microflora balance with a simplified probiotic formula
- Individuals with digestive discomfort seeking Lactobacillus and Bifidobacterium support
- Practitioners requiring a hypoallergenic, multi-strain probiotic for foundational GI protocols
Considerations
- Severely immunocompromised (consult physician)
- Active pancreatitis
- Central venous catheters (risk of translocation)
- SIBO (some probiotics may worsen — consult practitioner)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Colonization Begins
Beneficial bacteria begin establishing colonies
GI Improvement
Reduced bloating, improved regularity
Immune Modulation
Enhanced immune markers, fewer infections
Microbiome Shift
Sustained diversity improvement
Based on clinical probiotic research. Initial die-off symptoms (temporary bloating) may occur in the first week.
Compare the options
Compare Probiotic Types
Which strain type is right for you?
| Feature | Multi-Strain (this) | Spore-Based | Saccharomyces | Single-Strain |
|---|---|---|---|---|
| Survivability | Moderate (refrigerate) | Excellent (shelf-stable) | Excellent (yeast-based) | Moderate |
| Best For | General gut health | Antibiotic recovery | Diarrhea, C. diff | Targeted conditions |
| CFU Range | 10-100 billion | 2-5 billion (potent) | 5-10 billion | 1-50 billion |
| Research | Extensive | Growing | Strong (S. boulardii) | Strain-specific |
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These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
A few useful answers.
Research & further reading
More category questions
How many CFU do I need in a probiotic?
For general health maintenance, 10-20 billion CFU is sufficient. For therapeutic use (post-antibiotics, IBS, immune support), 50-100 billion CFU is recommended. More important than CFU count is strain diversity and survivability — a 5 billion spore-based probiotic may be more effective than a 100 billion conventional strain that doesn't survive stomach acid.
Should I take probiotics with food or on an empty stomach?
Take with food or within 30 minutes of eating. Food buffers stomach acid and increases probiotic survival by up to 100x. A small amount of fat in the meal further improves survival. Exception: spore-based probiotics (Bacillus strains) are acid-resistant and can be taken anytime.
Can probiotics cause bloating at first?
Yes — temporary bloating, gas, or changes in bowel habits during the first 3-7 days is common and actually a positive sign. This 'die-off' reaction occurs as beneficial bacteria displace harmful organisms. If symptoms persist beyond 2 weeks, reduce the dose by half and gradually increase.
Do I need to refrigerate probiotics?
It depends on the strain. Most Lactobacillus and Bifidobacterium strains require refrigeration for viability. Spore-based probiotics (Bacillus) and Saccharomyces boulardii are shelf-stable. Check the label — if it says 'viable at time of manufacture' rather than 'at time of expiration,' refrigerate.
Can I take probiotics with antibiotics?
Yes — in fact, it's strongly recommended. Take the probiotic 2-3 hours apart from the antibiotic dose (so the antibiotic doesn't kill the probiotic). Saccharomyces boulardii is particularly resistant to antibiotics. Continue probiotics for at least 2-4 weeks after completing the antibiotic course.
How long should I take probiotics?
For acute use (post-antibiotics, traveler's diarrhea), 4-8 weeks minimum. For chronic conditions (IBS, immune support), ongoing daily use is recommended. Probiotics don't permanently colonize — they exert benefits while you take them and for a limited time after stopping. Think of them as a daily maintenance supplement, not a one-time fix.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.