Vitamin D3 & K2, 120 Capsules
Pure Encapsulations Vitamin D3 & K2 combines cholecalciferol (D3) with menaquinone-7 (MK-7), a highly bioavailable form of vitamin K2, in a single hypoallergenic capsule.
May be a fit for
- Adults seeking D3 and K2 for combined bone mineralization support
- Individuals with limited sun exposure looking to maintain D3 levels
- Practitioners protocols requiring K2 to support proper calcium utilization
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Pure Encapsulations Vitamin D3 & K2 combines cholecalciferol (D3) with menaquinone-7 (MK-7), a highly bioavailable form of vitamin K2, in a single hypoallergenic capsule. This pairing supports calcium utilization, bone density maintenance, and cardiovascular health for adults looking to optimize both skeletal and arterial function.
Why It's Worth Considering: Pure Encapsulations formulates with MK-7 derived from natto, chosen for its extended half-life and superior tissue distribution compared to shorter-chain K2 forms, a detail that reflects the brand's clinically informed approach.
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Pure Encapsulations · 120 CapsulesMake it part of your routine.
As a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.
Important cautions & interactions
Storage
Store in a cool, dry place.
Product details
Supplement facts & complete label
Supplement Facts — Serving size: 1 capsule. Servings per container: 120.
Vitamin D (as cholecalciferol, D3): 100 mcg (4,000 IU).
Vitamin K2 (as menaquinone-7): 100 mcg.
Other ingredients: vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose).
Label directions
As a dietary supplement, take 1 capsule daily, with a meal or as directed by a health professional.
Label cautions
Vitamin K may be contraindicated with Coumadin (Warfarin). If you are pregnant or lactating, have any health condition or are taking any medication, particularly blood-thinning medication, consult your health professional before use. It is recommended that individuals taking more than 50 mcg (2,000 IU) vitamin D per day have their blood levels monitored.
Storage
Store in a cool, dry place.
Source: Pure Encapsulations manufacturer label · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking D3 and K2 for combined bone mineralization support
- Individuals with limited sun exposure looking to maintain D3 levels
- Practitioners protocols requiring K2 to support proper calcium utilization
- Those supporting cardiovascular health with combined D3 and K2 dosing
Considerations
- Hypercalcemia (elevated blood calcium)
- Sarcoidosis or other granulomatous diseases
- Severe kidney disease without medical supervision
- Taking thiazide diuretics (monitor calcium)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Serum Levels Rise
Measurable increase in 25(OH)D
Immune Support
Improved innate immune function
Mood & Energy
Reduced fatigue and improved mood
Optimal Range
Target 50-80 ng/mL achieved
Based on clinical studies on vitamin D3 supplementation. Response varies by baseline levels, body weight, and skin tone.
Compare the options
Compare Vitamin D Forms
D3 vs D2 vs D3+K2
| Feature | D3 (Cholecalciferol) | D2 (Ergocalciferol) | D3 + K2 Combo |
|---|---|---|---|
| Source | Animal (lanolin/lichen) | Plant/fungal | Animal + bacterial |
| Potency | 87% more effective at raising serum D | Baseline | Same as D3 + K2 synergy |
| Half-Life | ~2-3 weeks | ~2-3 days | ~2-3 weeks |
| Best For | General supplementation | Vegan-only option | Bone + cardiovascular health |
| Evidence | Strong (gold standard) | Moderate | Strong (synergistic) |
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Customer reviews, social conversations and expert insights, with every source in view.
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Coverage varies by product and brand.
666 product and brand ratings and mentions across 6 sources.
These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
Explore the source sentiment summary
Strong belief in D3+K2 benefits for immunity and bone health, but significant frustration with mainstream dosage guidelines being too low.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
How much vitamin D3 should I take daily?
Most functional medicine practitioners recommend 5,000 IU daily for adults with normal BMI, and up to 10,000 IU for those with obesity or severe deficiency. The Endocrine Society recommends maintaining serum 25(OH)D levels between 40-60 ng/mL. Test your levels every 3-6 months.
Is vitamin D3 better than D2?
Yes. D3 (cholecalciferol) is 87% more effective at raising and maintaining serum vitamin D levels compared to D2 (ergocalciferol). D3 also has a longer half-life. D2 is only preferred by strict vegans who cannot use lanolin-sourced D3 — lichen-based D3 is the vegan alternative.
Should I take vitamin D3 with vitamin K2?
Yes, especially at doses above 2,000 IU. Vitamin D3 increases calcium absorption from food. Without K2, that calcium can deposit in arteries instead of bones. K2 (MK-7 form) activates osteocalcin (puts calcium in bones) and matrix GLA protein (keeps calcium out of arteries).
Can I take too much vitamin D?
Toxicity is rare below 10,000 IU/day in healthy adults but possible with chronic high-dose use without monitoring. Symptoms of excess include hypercalcemia (nausea, kidney stones, confusion). Always pair high-dose D3 with K2 and test 25(OH)D levels every 3-6 months.
When is the best time to take vitamin D3?
Take with your largest meal containing fat — D3 is fat-soluble and absorption increases 30-50% when taken with dietary fat. Morning or afternoon is preferred over evening, as some studies suggest late-night D3 may interfere with melatonin production.
How long does it take for vitamin D levels to increase?
Serum 25(OH)D typically rises within 1-2 weeks of supplementation. Reaching optimal range (50-80 ng/mL) takes 2-3 months at 5,000 IU/day from a deficient baseline. Higher loading doses (10,000 IU for 8 weeks then maintenance) can accelerate this.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.