Strong consensus that K2+D3 offers significant cardiovascular and bone benefits, though rare side effects like palpitations and calcium concerns warrant caution.
Source Naturals Vitamin K2 + D3 combines menaquinone-7 (MK-7), a long-acting form of K2 derived from fermentation, with cholecalciferol (D3) to support calcium metabolism, bone density maintenance, and cardiovascular health. This pairing is designed for adults seeking to optimize how calcium is directed in the body — toward bones rather than soft tissues.
Why It's Worth Considering: MK-7 offers a longer half-life than MK-4, making it a well-regarded choice for sustained K2 activity, and pairing it with D3 reflects how these two nutrients work synergistically in calcium regulation.
Vitamin K1 (phylloquinone) is for blood clotting — abundant in leafy greens. Vitamin K2 (menaquinone) directs calcium metabolism — puts calcium in bones and keeps it out of arteries. Most people get enough K1 from diet but are deficient in K2, which is found mainly in fermented foods (natto, certain cheeses) and animal liver.
MK-7 is the most bioavailable and longest-acting form of K2, with a half-life of ~3 days (vs ~1 hour for MK-4). This means a single daily dose maintains therapeutic blood levels 24/7. MK-7 is derived from natto (fermented soybeans) and has the strongest clinical evidence for bone density and arterial health.
For general health with D3: 100-200mcg MK-7 daily. For osteoporosis: 180-360mcg. For cardiovascular calcification prevention: 180-200mcg. The dose should scale with your D3 intake — higher D3 doses require more K2 to handle the increased calcium absorption.
If you're on warfarin/Coumadin: NO — K2 counteracts warfarin and will destabilize your INR. Consult your cardiologist. If you're on newer anticoagulants (Eliquis/apixaban, Xarelto/rivaroxaban, Pradaxa/dabigatran): these are NOT vitamin K-dependent, so K2 is safe. Always confirm with your prescribing physician.
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No significant interactions identified. Always consult your healthcare provider.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
