Betaine HCL & Pepsin, 225 Capsules
Size: 225 capsules
May be a fit for
- Adults seeking betaine HCL to support healthy stomach acid levels
- Individuals who experience bloating or heaviness after protein-rich meals
- Practitioners protocols requiring pepsin co-supplementation for protein digestion support
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Thorne's Betaine HCL & Pepsin delivers hydrochloric acid precursor alongside the protein-digesting enzyme pepsin in a single capsule formula designed to support gastric acid levels and protein breakdown. It's aimed at individuals who experience digestive discomfort, bloating, or a sense of heaviness after protein-rich meals, common signs of suboptimal stomach acid production.
Why It's Worth Considering: Thorne is a practitioner-trusted brand known for rigorous raw material testing and clean excipients; this 225-capsule size offers extended supply with flexible dose titration that digestive support protocols often require.
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Thorne · 225 CapsulesMake it part of your routine.
Take 1-2 capsules with each meal or as recommended by your health professional.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size:
Two Capsules
Amount Per Serving:
Betaine Hydrochloride† ... 1 g
Pepsin (Porcine) ... 47 mg
Other Ingredients:
Calcium Laurate, Hypromellose Capsule, Leucine, Silicon Dioxide
ALLERGY WARNINGS
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health professional before using this product.
INTERACTIONS/CONTRAINDICATIONS
Betaine HCL & Pepsin should not be used concurrently with H2-blocking drugs and proton pump inhibitors, because these drugs are intended to block the production of stomach HCl.
OTHER WARNINGS
Betaine HCL & Pepsin is contraindicated in patients with peptic ulcers. It is not recommended to remove the Betaine HCL & Pepsin powder from the capsule to take orally, as it can be irritating to the oral mucosa.
Label directions
Take 1-2 capsules with each meal or as recommended by your health professional.
Open original label ↗
Source: authorized supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking betaine HCL to support healthy stomach acid levels
- Individuals who experience bloating or heaviness after protein-rich meals
- Practitioners protocols requiring pepsin co-supplementation for protein digestion support
- Those supporting gastric enzyme activity during low-stomach-acid concerns
Considerations
- Active stomach or duodenal ulcers (especially betaine HCl)
- Taking blood thinners (some enzymes have mild anti-platelet activity)
- Active pancreatitis
Explore complementary products
NOW Foods - Aloe 10,000 & Probiotics, 60 CapsulesEnzymes break down food mechanically while probiotics optimize the microbiome. Together they address both aspects of digestion.$19.99
Thorne - L-Glutamine Powder, 513 gEnzymes improve digestion while glutamine repairs the intestinal lining. The two-pronged approach to gut healing.$67.99
Thorne - Betaine HCL & Pepsin, 225 CapsulesMany people have LOW stomach acid (not high). Betaine HCl restores acid while enzymes handle the downstream breakdown.$47.99Real reviews. A wider perspective.
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1607 product and brand ratings and mentions across 6 sources.
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Brand trust severely undermined by PE/LVMH acquisition, R&D team cuts, Amazon counterfeits, and CoA refusals, despite some praise for formulation.
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A few useful answers.
Research & further reading
More category questions
When should I take digestive enzymes?
Take immediately before or with the first bites of your meal. Enzymes need to be in the stomach when food arrives. Taking them after eating is less effective. For best results, take with every substantial meal — especially meals high in fat, protein, or hard-to-digest foods.
Do I need enzymes if I take probiotics?
They serve different functions. Enzymes physically break down food into absorbable nutrients. Probiotics are living bacteria that optimize the gut microbiome, produce vitamins, and support immune function. Many gut issues benefit from both — especially after age 40 when natural enzyme production declines.
Can I become dependent on digestive enzymes?
No. Digestive enzymes do not cause your body to produce fewer of its own enzymes. They supplement what your body is already making (or under-making). You can stop taking them anytime without withdrawal or rebound. If your symptoms return after stopping, it means you still need the support — not that you've become dependent.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.