D-5000 NSF, 120 Capsules
Thorne D-5000 delivers 5,000 IU of vitamin D3 (cholecalciferol) per capsule, the same bioidentical form the body synthesizes from sunlight, to support bone density, immune function, and healthy calcium metabolism.
May be a fit for
- Adults with lab-confirmed low 25(OH)D seeking cholecalciferol repletion
- Practitioners protocols requiring 5,000 IU vitamin D3 for clinical repletion
- Individuals with limited sun exposure needing sustained cholecalciferol support
Save together with Wellness Circles
Invite friends or family to a Wellness Circle. Your group can unlock savings together. See current tiers and terms before joining.
Explore Wellness CirclesA closer look.
Thorne D-5000 delivers 5,000 IU of vitamin D3 (cholecalciferol) per capsule, the same bioidentical form the body synthesizes from sunlight, to support bone density, immune function, and healthy calcium metabolism. Formulated for adults with higher vitamin D needs, including those with limited sun exposure or confirmed insufficiency.
Why It's Worth Considering: Thorne's NSF Certified for Sport designation means this product has been independently tested for label accuracy and banned substance absence, a standard that appeals to athletes and clinically-minded practitioners alike.
Product details
Who it may suit
May be a fit for
- Adults with lab-confirmed low 25(OH)D seeking cholecalciferol repletion
- Practitioners protocols requiring 5,000 IU vitamin D3 for clinical repletion
- Individuals with limited sun exposure needing sustained cholecalciferol support
- Athletes in NSF Certified for Sport programs requiring verified vitamin D3
Considerations
- Hypercalcemia (elevated blood calcium)
- Sarcoidosis or other granulomatous diseases
- Severe kidney disease without medical supervision
- Taking thiazide diuretics (monitor calcium)
What to expect over time
Serum Levels Rise
Measurable increase in 25(OH)D
Immune Support
Improved innate immune function
Mood & Energy
Reduced fatigue and improved mood
Optimal Range
Target 50-80 ng/mL achieved
Based on clinical studies on vitamin D3 supplementation. Response varies by baseline levels, body weight, and skin tone.
Compare the options
Compare Vitamin D Forms
D3 vs D2 vs D3+K2
| Feature | D3 (Cholecalciferol) | D2 (Ergocalciferol) | D3 + K2 Combo |
|---|---|---|---|
| Source | Animal (lanolin/lichen) | Plant/fungal | Animal + bacterial |
| Potency | 87% more effective at raising serum D | Baseline | Same as D3 + K2 synergy |
| Half-Life | ~2-3 weeks | ~2-3 days | ~2-3 weeks |
| Best For | General supplementation | Vegan-only option | Bone + cardiovascular health |
| Evidence | Strong (gold standard) | Moderate | Strong (synergistic) |
Explore complementary products
Protocol for Life Balance - Vitamin K2 (MK-7) 300 mcg, 60 CapsulesK2 directs D3-absorbed calcium into bones instead of arteries. The D3+K2 combination is critical for cardiovascular safety at doses above 2000 IU.$37.99
Pure Encapsulations - Magnesium (Glycinate), 180 CapsulesMagnesium is required to convert vitamin D into its active form. Without adequate Mg, high-dose D3 is less effective.$46.99
Source Naturals - ArcticPure® Ultra Potency Omega-3 Fish OilD3 is fat-soluble — taking with omega-3s improves absorption by 30-50%. They also synergize for inflammation reduction.$16.99
Pure Encapsulations - Zinc 30, 180 CapsulesD3 + Zinc is the foundational immune support stack. Both are commonly deficient and both regulate immune cell function.$40.99Real reviews. A wider perspective.
Customer reviews, social conversations and expert insights, with every source in view.
- Marketplaces & brand websites
- Amazon, iHerb and direct brand reviews
- Social & community
- Reddit, X, Instagram and TikTok
- Video & creators
- YouTube and creator perspectives
Coverage varies by product and brand.
These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
A few useful answers.
Research & further reading
More category questions
How much vitamin D3 should I take daily?
Most functional medicine practitioners recommend 5,000 IU daily for adults with normal BMI, and up to 10,000 IU for those with obesity or severe deficiency. The Endocrine Society recommends maintaining serum 25(OH)D levels between 40-60 ng/mL. Test your levels every 3-6 months.
Is vitamin D3 better than D2?
Yes. D3 (cholecalciferol) is 87% more effective at raising and maintaining serum vitamin D levels compared to D2 (ergocalciferol). D3 also has a longer half-life. D2 is only preferred by strict vegans who cannot use lanolin-sourced D3 — lichen-based D3 is the vegan alternative.
Should I take vitamin D3 with vitamin K2?
Yes, especially at doses above 2,000 IU. Vitamin D3 increases calcium absorption from food. Without K2, that calcium can deposit in arteries instead of bones. K2 (MK-7 form) activates osteocalcin (puts calcium in bones) and matrix GLA protein (keeps calcium out of arteries).
Can I take too much vitamin D?
Toxicity is rare below 10,000 IU/day in healthy adults but possible with chronic high-dose use without monitoring. Symptoms of excess include hypercalcemia (nausea, kidney stones, confusion). Always pair high-dose D3 with K2 and test 25(OH)D levels every 3-6 months.
When is the best time to take vitamin D3?
Take with your largest meal containing fat — D3 is fat-soluble and absorption increases 30-50% when taken with dietary fat. Morning or afternoon is preferred over evening, as some studies suggest late-night D3 may interfere with melatonin production.
How long does it take for vitamin D levels to increase?
Serum 25(OH)D typically rises within 1-2 weeks of supplementation. Reaching optimal range (50-80 ng/mL) takes 2-3 months at 5,000 IU/day from a deficient baseline. Higher loading doses (10,000 IU for 8 weeks then maintenance) can accelerate this.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.