K2-D3 10,000 (Vitamin D3), 60 Capsules
Xymogen's K2-D3 10,000 delivers 10,000 IU of cholecalciferol (vitamin D3) paired with vitamin K2 as MK-7, a long-acting menaquinone form that supports proper calcium utilization in the body.
May be a fit for
- Adults with clinically low vitamin D levels seeking high-dose D3 repletion
- Practitioners protocols requiring 10,000 IU D3 with K2 co-factor support
- Those supporting calcium metabolism with combined K2 and D3 dosing
Save together with Wellness Circles
Invite friends or family to a Wellness Circle. Your group can unlock savings together. See current tiers and terms before joining.
Explore Wellness CirclesA closer look.
Xymogen's K2-D3 10,000 delivers 10,000 IU of cholecalciferol (vitamin D3) paired with vitamin K2 as MK-7, a long-acting menaquinone form that supports proper calcium utilization in the body. This combination is designed to support bone density, cardiovascular health, and immune function for individuals with clinically confirmed vitamin D insufficiency or higher physiological needs.
Why It's Worth Considering: Pairing D3 with MK-7 at this dose addresses a common clinical concern, that high-dose vitamin D supplementation without K2 may direct calcium to soft tissues rather than bone. Xymogen formulates to practitioner-grade standards with tightly controlled raw material sourcing.
50+ signals. A clearer standard.
Our curation and trust scoring bring together manufacturing, testing, research, practitioner insight and reviews from across the web.
Our score is an editorial assessment, not a product certification or a guarantee of results.
Xymogen · 60 CapsulesMake it part of your routine.
Swallow one capsule daily with water, preferably at mealtime, or as directed by your healthcare professional.
Important cautions & interactions
Product details
Supplement facts & complete label
Serving Size:
1 Capsule
Amount Per Serving:
Vitamin D3 (cholecalciferol) ... 250 mcg (10,000 IU)
Vitamin K2 (as menaquinone-7) ... 45 mcg
Other Ingredients:
Microcrystalline cellulose, capsule (hypromellose and water), vegetable stearic acid, vegetable magnesium stearate, and silica.
Label directions
Swallow one capsule daily with water, preferably at mealtime, or as directed by your healthcare professional.
Label cautions
Consult your healthcare professional before use. Individuals taking blood thinners or other medications should discuss potential interactions with their healthcare professional. Do not use if tamper seal is damaged. Keep closed in a cool, dry place out of reach of children.
Source: authorized supplier original manufacturer label · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults with clinically low vitamin D levels seeking high-dose D3 repletion
- Practitioners protocols requiring 10,000 IU D3 with K2 co-factor support
- Those supporting calcium metabolism with combined K2 and D3 dosing
- Individuals with limited sun exposure seeking meaningful vitamin D3 intake
Considerations
- Hypercalcemia (elevated blood calcium)
- Sarcoidosis or other granulomatous diseases
- Severe kidney disease without medical supervision
- Taking thiazide diuretics (monitor calcium)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Serum Levels Rise
Measurable increase in 25(OH)D
Immune Support
Improved innate immune function
Mood & Energy
Reduced fatigue and improved mood
Optimal Range
Target 50-80 ng/mL achieved
Based on clinical studies on vitamin D3 supplementation. Response varies by baseline levels, body weight, and skin tone.
Compare the options
Compare Vitamin D Forms
D3 vs D2 vs D3+K2
| Feature | D3 (Cholecalciferol) | D2 (Ergocalciferol) | D3 + K2 Combo |
|---|---|---|---|
| Source | Animal (lanolin/lichen) | Plant/fungal | Animal + bacterial |
| Potency | 87% more effective at raising serum D | Baseline | Same as D3 + K2 synergy |
| Half-Life | ~2-3 weeks | ~2-3 days | ~2-3 weeks |
| Best For | General supplementation | Vegan-only option | Bone + cardiovascular health |
| Evidence | Strong (gold standard) | Moderate | Strong (synergistic) |
Explore complementary products
Protocol for Life Balance - Vitamin K2 (MK-7) 300 mcg, 60 CapsulesK2 activates osteocalcin to direct D3-absorbed calcium into bone, not arteries.$37.99
Pure Encapsulations - Magnesium (Glycinate), 180 CapsulesMagnesium is required for D3 conversion to active calcitriol — deficiency limits D3 effectiveness.$46.99
Source Naturals - ArcticPure® Ultra Potency Omega-3 Fish OilFat-soluble pairing for cardiovascular and immune support.$16.99Real reviews. A wider perspective.
Customer reviews, social conversations and expert insights, with every source in view.
- Marketplaces & brand websites
- Amazon, iHerb and direct brand reviews
- Social & community
- Reddit, X, Instagram and TikTok
- Video & creators
- YouTube and creator perspectives
Coverage varies by product and brand.
155 product and brand ratings and mentions across 4 sources.
These are broader practitioner and research perspectives. They may discuss the brand or other products, rather than this exact formula.
Explore the source sentiment summary
Generally positive consensus on Vitamin D3 supplementation for deficiency and immunity, with debate around optimal dosing and K2 co-supplementation.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
How much vitamin D3 should I take daily?
Most functional medicine practitioners recommend 5,000 IU daily for adults with normal BMI, and up to 10,000 IU for those with obesity or severe deficiency. The Endocrine Society recommends maintaining serum 25(OH)D levels between 40-60 ng/mL. Test your levels every 3-6 months.
Is vitamin D3 better than D2?
Yes. D3 (cholecalciferol) is 87% more effective at raising and maintaining serum vitamin D levels compared to D2 (ergocalciferol). D3 also has a longer half-life. D2 is only preferred by strict vegans who cannot use lanolin-sourced D3 — lichen-based D3 is the vegan alternative.
Should I take vitamin D3 with vitamin K2?
Yes, especially at doses above 2,000 IU. Vitamin D3 increases calcium absorption from food. Without K2, that calcium can deposit in arteries instead of bones. K2 (MK-7 form) activates osteocalcin (puts calcium in bones) and matrix GLA protein (keeps calcium out of arteries).
Can I take too much vitamin D?
Toxicity is rare below 10,000 IU/day in healthy adults but possible with chronic high-dose use without monitoring. Symptoms of excess include hypercalcemia (nausea, kidney stones, confusion). Always pair high-dose D3 with K2 and test 25(OH)D levels every 3-6 months.
When is the best time to take vitamin D3?
Take with your largest meal containing fat — D3 is fat-soluble and absorption increases 30-50% when taken with dietary fat. Morning or afternoon is preferred over evening, as some studies suggest late-night D3 may interfere with melatonin production.
How long does it take for vitamin D levels to increase?
Serum 25(OH)D typically rises within 1-2 weeks of supplementation. Reaching optimal range (50-80 ng/mL) takes 2-3 months at 5,000 IU/day from a deficient baseline. Higher loading doses (10,000 IU for 8 weeks then maintenance) can accelerate this.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.