K2-D3 5000 (Vitamin D3), 60 Capsules
K2-D3 5000 from Xymogen combines 5,000 IU of cholecalciferol (vitamin D3) with vitamin K2 as MK-7, a long-acting menaquinone form that supports healthy calcium utilization and bone mineralization.
May be a fit for
- Adults maintaining bone density with vitamin D3 and K2 synergy
- Those with limited sun exposure seeking vitamin D3 repletion
- Practitioner protocols requiring high-dose 5000 IU vitamin D3 support
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K2-D3 5000 from Xymogen combines 5,000 IU of cholecalciferol (vitamin D3) with vitamin K2 as MK-7, a long-acting menaquinone form that supports healthy calcium utilization and bone mineralization. This pairing is designed for adults seeking to support immune function, skeletal integrity, and cardiovascular wellness through complementary fat-soluble nutrient pathways.
Why It's Worth Considering: Xymogen is a practitioner-grade brand, and this formulation uses MK-7 specifically for its extended half-life and superior bioavailability compared to shorter-chain K2 forms, a meaningful distinction at higher D3 doses.
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Product details
Who it may suit
May be a fit for
- Adults maintaining bone density with vitamin D3 and K2 synergy
- Those with limited sun exposure seeking vitamin D3 repletion
- Practitioner protocols requiring high-dose 5000 IU vitamin D3 support
- Individuals supporting calcium utilization through combined K2-D3 supplementation
Considerations
- Hypercalcemia (elevated blood calcium)
- Sarcoidosis or other granulomatous diseases
- Severe kidney disease without medical supervision
- Taking thiazide diuretics (monitor calcium)
Compatibility & interactions
Works Well With
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Serum Levels Rise
Measurable increase in 25(OH)D
Immune Support
Improved innate immune function
Mood & Energy
Reduced fatigue and improved mood
Optimal Range
Target 50-80 ng/mL achieved
Based on clinical studies on vitamin D3 supplementation. Response varies by baseline levels, body weight, and skin tone.
Compare the options
Compare Vitamin D Forms
D3 vs D2 vs D3+K2
| Feature | D3 (Cholecalciferol) | D2 (Ergocalciferol) | D3 + K2 Combo |
|---|---|---|---|
| Source | Animal (lanolin/lichen) | Plant/fungal | Animal + bacterial |
| Potency | 87% more effective at raising serum D | Baseline | Same as D3 + K2 synergy |
| Half-Life | ~2-3 weeks | ~2-3 days | ~2-3 weeks |
| Best For | General supplementation | Vegan-only option | Bone + cardiovascular health |
| Evidence | Strong (gold standard) | Moderate | Strong (synergistic) |
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Customer reviews, social conversations and expert insights, with every source in view.
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Coverage varies by product and brand.
155 product and brand ratings and mentions across 4 sources.
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Explore the source sentiment summary
General consensus favors D3 supplementation for immunity and bone health, but significant debate exists around proper dosing and institutional guidelines.
This summary includes broader brand discussion. Individual experiences are not evidence of product effectiveness.
A few useful answers.
Research & further reading
More category questions
How much vitamin D3 should I take daily?
Most functional medicine practitioners recommend 5,000 IU daily for adults with normal BMI, and up to 10,000 IU for those with obesity or severe deficiency. The Endocrine Society recommends maintaining serum 25(OH)D levels between 40-60 ng/mL. Test your levels every 3-6 months.
Is vitamin D3 better than D2?
Yes. D3 (cholecalciferol) is 87% more effective at raising and maintaining serum vitamin D levels compared to D2 (ergocalciferol). D3 also has a longer half-life. D2 is only preferred by strict vegans who cannot use lanolin-sourced D3 — lichen-based D3 is the vegan alternative.
Should I take vitamin D3 with vitamin K2?
Yes, especially at doses above 2,000 IU. Vitamin D3 increases calcium absorption from food. Without K2, that calcium can deposit in arteries instead of bones. K2 (MK-7 form) activates osteocalcin (puts calcium in bones) and matrix GLA protein (keeps calcium out of arteries).
Can I take too much vitamin D?
Toxicity is rare below 10,000 IU/day in healthy adults but possible with chronic high-dose use without monitoring. Symptoms of excess include hypercalcemia (nausea, kidney stones, confusion). Always pair high-dose D3 with K2 and test 25(OH)D levels every 3-6 months.
When is the best time to take vitamin D3?
Take with your largest meal containing fat — D3 is fat-soluble and absorption increases 30-50% when taken with dietary fat. Morning or afternoon is preferred over evening, as some studies suggest late-night D3 may interfere with melatonin production.
How long does it take for vitamin D levels to increase?
Serum 25(OH)D typically rises within 1-2 weeks of supplementation. Reaching optimal range (50-80 ng/mL) takes 2-3 months at 5,000 IU/day from a deficient baseline. Higher loading doses (10,000 IU for 8 weeks then maintenance) can accelerate this.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.