Vitamin B Complex (formerly Glycogenics®), 60 Tablets
Metagenics Vitamin B Complex (formerly Glycogenics®) delivers a comprehensive spectrum of B vitamins, including active, coenzyme forms such as methylcobalamin, pyridoxal-5-phosphate, and riboflavin-5-phosphate, to support energy metabolism, nervous system function, and healthy homocysteine levels.
May be a fit for
- Adults seeking activated B vitamins including methylcobalamin and pyridoxal-5-phosphate
- Practitioners supporting patients with compromised B vitamin metabolism or absorption
- Individuals maintaining homocysteine levels already within normal range with B-complex cofactors
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Metagenics Vitamin B Complex (formerly Glycogenics®) delivers a comprehensive spectrum of B vitamins, including active, coenzyme forms such as methylcobalamin, pyridoxal-5-phosphate, and riboflavin-5-phosphate, to support energy metabolism, nervous system function, and healthy homocysteine levels. Formulated by Metagenics, a practitioner-trusted brand with a focus on clinical-grade nutrient delivery, this product is designed for individuals who may have difficulty converting standard B vitamins into their bioavailable forms.
Why It's Worth Considering: The inclusion of pre-converted, metabolically active B vitamin forms reduces reliance on individual enzymatic conversion, making this a practical option for those with MTHFR variants or other metabolic considerations.
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Product details
Who it may suit
May be a fit for
- Adults seeking activated B vitamins including methylcobalamin and pyridoxal-5-phosphate
- Practitioners supporting patients with compromised B vitamin metabolism or absorption
- Individuals maintaining homocysteine levels already within normal range with B-complex cofactors
- Those supporting neurological function and cellular energy metabolism with complete B vitamin spectrum
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
Compatibility & interactions
Works Well With
Ask Gabriel for personalized stacking recommendations.
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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Metagenics is widely respected by practitioners and consumers for quality, but pricing and ownership concerns temper enthusiasm.
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.