PureGenomics B-Complex, 120 Capsules
PureGenomics B-Complex from Pure Encapsulations delivers a full spectrum of B vitamins in their active, coenzyme forms, including methylfolate (5-MTHF), methylcobalamin, and pyridoxal-5-phosphate, formulated to support individuals with common methylation-related genetic variants such as MTHFR.
May be a fit for
- Adults seeking activated B-vitamins matched to common MTHFR variants
- Practitioners protocols requiring methylfolate and methylcobalamin in one formula
- Individuals with suboptimal folate metabolism supporting healthy homocysteine levels
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PureGenomics B-Complex from Pure Encapsulations delivers a full spectrum of B vitamins in their active, coenzyme forms, including methylfolate (5-MTHF), methylcobalamin, and pyridoxal-5-phosphate, formulated to support individuals with common methylation-related genetic variants such as MTHFR. This targeted formulation supports healthy methylation pathways, neurological function, and energy metabolism.
Why It's Worth Considering: Designed in alignment with the PureGenomics platform, this formula uses pre-converted, biologically active B vitamin forms that bypass enzymatic conversion steps that some individuals are less able to complete efficiently.
Pure Encapsulations · 120 CapsulesMake it part of your routine.
As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Important cautions & interactions
Storage
Store in a cool, dry place.
Product details
Supplement facts & complete label
Supplement Facts — Serving size: 1 capsule. Servings per container: 120.
Thiamin (as thiamin HCl): 25 mg.
Riboflavin (as vitamin B2 and 67% riboflavin 5′-phosphate): 15 mg.
Niacin (as niacinamide): 50 mg.
Vitamin B6 (as pyridoxine HCl and 20% pyridoxal 5′-phosphate): 50 mg.
Folate (as Metafolin®, L-5-MTHF): 1,333 mcg DFE (800 mcg L-5-MTHF).
Vitamin B12 (as adenosylcobalamin and 50% hydroxycobalamin): 800 mcg.
Biotin: 400 mcg.
Pantothenic acid (as calcium pantothenate): 100 mg.
Choline (as choline bitartrate): 40 mg.
Inositol: 25 mg.
BenfoPure® benfotiamine: 3 mg.
Other ingredients: vegetarian capsule (cellulose, water), hypoallergenic plant fiber (cellulose), ascorbyl palmitate.
Label directions
As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Label cautions
If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.
Storage
Store in a cool, dry place.
Source: Pure Encapsulations manufacturer label · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking activated B-vitamins matched to common MTHFR variants
- Practitioners protocols requiring methylfolate and methylcobalamin in one formula
- Individuals with suboptimal folate metabolism supporting healthy homocysteine levels
- Those supporting neurological function with riboflavin-5-phosphate and P-5-P forms
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
Compatibility & interactions
Works Well With
Ask Gabriel for personalized stacking recommendations.
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.