Ultra B-Complex w/PQQ, 60 Capsules
Ultra B-Complex with PQQ from Pure Encapsulations combines a full-spectrum B-vitamin complex with pyrroloquinoline quinone (PQQ), a compound that supports mitochondrial biogenesis and cellular energy metabolism.
May be a fit for
- Adults seeking methylated B vitamins alongside PQQ for cellular energy support
- Clinicians protocols requiring active B-complex forms for patients with MTHFR variants
- Individuals supporting mitochondrial function with PQQ and B-vitamin cofactors
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Ultra B-Complex with PQQ from Pure Encapsulations combines a full-spectrum B-vitamin complex with pyrroloquinoline quinone (PQQ), a compound that supports mitochondrial biogenesis and cellular energy metabolism. Formulated with activated B-vitamin forms, including methylfolate, methylcobalamin, and riboflavin-5-phosphate, it's designed for those seeking comprehensive neurological and metabolic support.
Why It's Worth Considering: Pure Encapsulations uses activated, coenzymated B-vitamin forms that bypass common metabolic conversion steps, which may be especially relevant for individuals with MTHFR variants or impaired methylation capacity.
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Pure Encapsulations · 60 CapsulesMake it part of your routine.
As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size: 1 capsule
Amount Per Serving
Thiamin ... 125mg
(as thiamin HCl)
Riboflavin ... 12.7mg
(vitamin B2 and 60% riboflavin 5’ phosphate (activated B2))
Niacin ... 108mg
(as niacinamide and 8% inositol hexaniacinate (no-flush niacin))
Vitamin B6 ... 96.7mg
(as pyridoxine HCl and 7% pyridoxal 5’ phosphate (activated B6))
Folate ... 667mcg DFE
(as Metafolin®, L-5-MTHF) (400 mcg L-5-MTHF)
Vitamin B12 ... 1,000mcg
(as methylcobalamin and 50% adenosylcobalamin)
Biotin ... 400mcg
Panthothenic acid ... 100mg
(as calcium pantothenate) (B5)
Alpha lipoic acid ... 100mg
(thioctic acid)
Luteolin ... 20mg
BioPQQ® pyrroloquinoline quinone ... 10mg
disodium salt
Other ingredients: vegetarian capsule (cellulose, water), ascorbyl palmitate
BioPQQ® is a trademark of MGC (Japan)
If pregnant or lactating, consult your physician before taking this product. Alpha lipoic acid has been associated with nausea and skin rash in some sensitive individuals. Luteolin is not recommended for individuals with sensitivity to botanicals from the Asteraceae/Compositae family. Consult your physician for more information.
Folic acid may adversely interact with chemotheraputic drugs. Consult your physician for more information.
Label directions
As a dietary supplement, take 1 capsule, 1-2 times daily, with meals.
Open original label ↗
Source: authorized supplier catalog · September 06, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking methylated B vitamins alongside PQQ for cellular energy support
- Clinicians protocols requiring active B-complex forms for patients with MTHFR variants
- Individuals supporting mitochondrial function with PQQ and B-vitamin cofactors
- Those maintaining cognitive clarity with folate, B12, and pyrroloquinoline quinone
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
Compatibility & interactions
Works Well With
Ask Gabriel for personalized stacking recommendations.
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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Pure Encapsulations is widely praised for quality and clean ingredients, though high prices are a recurring complaint and some users report no noticeable effect.
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.