5-MTHF 5mg, 60 Capsules
Thorne's 5-MTHF 5mg delivers methylfolate, the biologically active, pre-converted form of folate, in a clinically relevant 5mg dose per capsule.
May be a fit for
- Adults with MTHFR variants seeking active methylfolate supplementation
- Practitioners supporting methylation cycle function in sensitive patients
- Those seeking a methyl-donor form of folate without folic acid
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Thorne's 5-MTHF 5mg delivers methylfolate, the biologically active, pre-converted form of folate, in a clinically relevant 5mg dose per capsule. Unlike folic acid, 5-MTHF requires no conversion by the MTHFR enzyme, making it particularly relevant for individuals with common MTHFR gene variants. It supports methylation, cardiovascular health, and neurological function.
Why It's Worth Considering: Thorne uses a high-purity, stable form of 5-methyltetrahydrofolate without unnecessary fillers, consistent with their practitioner-grade manufacturing standards and NSF Certified for Sport status.
Thorne · 60 CapsulesMake it part of your routine.
Take 1 capsule one to two times daily or as recommended by your health professional.
Read the complete labelProduct details
Supplement facts & complete label
Serving Size:
One Capsule
Amount Per Serving:
Folate (5 mg as L-5-Methyltetrahydrofolate†) ... 8.3 mg DFE
Other Ingredients:
Hypromellose Capsule, Leucine, Microcrystalline Cellulose, Silicon Dioxide
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY WARNING
If pregnant, consult your health professional before using this product.
INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Label directions
Take 1 capsule one to two times daily or as recommended by your health professional.
Open original label ↗
Source: authorized supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults with MTHFR variants seeking active methylfolate supplementation
- Practitioners supporting methylation cycle function in sensitive patients
- Those seeking a methyl-donor form of folate without folic acid
- Individuals maintaining homocysteine levels already within normal range
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.