B-Complex #6 NSF, 60 Capsules
Size: 60 capsules
May be a fit for
- Adults seeking activated B-vitamin forms including pyridoxal-5-phosphate
- Individuals supporting energy metabolism with a complete B-complex
- Those with methylation concerns benefiting from coenzymated B6 and B12
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Thorne B-Complex #6 is a comprehensive B-vitamin formula providing all eight essential B vitamins in their active, coenzyme forms, including riboflavin 5'-phosphate, pyridoxal 5'-phosphate (P5P), and methylfolate, designed to support energy metabolism, nervous system function, and methylation pathways. It carries NSF Certified for Sport® certification, making it a sound choice for athletes and health-conscious individuals who require third-party verified purity.
Why It's Worth Considering: The use of bioavailable coenzyme forms bypasses conversion steps that some individuals, particularly those with MTHFR variants, may struggle with, and NSF certification provides an added layer of quality assurance.
Product details
Supplement facts & complete label
Ingredients are not derived from yeast
NSF Certified for Sport®
Because athletes need to know their supplements are trustworthy and compliant, every batch of an NSF Certified for Sport® product is tested for compliance with label claims and to ensure the absence of more than 200 substances banned by many major athletic organizations. Still unsure which B-Complex to choose? Take our B-Complex Quiz. https://www.thorne.com/quizzes/which-b-complex-is-best-for-me
Suggested Use / Directions:
Take 1 capsule daily or as recommended by your health professional.
Serving Size:
One Capsule
Amount Per Serving:
Thiamin (as Thiamin HCl) ... 40 mg
Riboflavin (25 mg as Riboflavin and 5 mg as Riboflavin 5’-Phosphate Sodium) ... 30 mg
Niacin (as Niacinamide) ... 80 mg
Vitamin B6 (85 mg from 106 mg as Pyridoxine HCl and 15 mg from 25 mg Pyridoxal 5’-Phosphate) ... 100 mg
Folate (200 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) ... 334 mcg DFE
Vitamin B12 (as Methylcobalamin) ... 100 mcg
Biotin ... 80 mcg
Pantothenic Acid (as Calcium Pantothenate) ... 45 mg
Choline (as Choline Citrate) ... 14 mg
Other Ingredients:
Calcium Laurate, Hypromellose Capsule, Microcrystalline Cellulose, Silicon Dioxide
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health professional before using this product.
INTERACTIONS/CONTRAINDICATIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Doses of vitamin B6 above 200 mg may inhibit breast milk production.
Source: authorized supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Who it may suit
May be a fit for
- Adults seeking activated B-vitamin forms including pyridoxal-5-phosphate
- Individuals supporting energy metabolism with a complete B-complex
- Those with methylation concerns benefiting from coenzymated B6 and B12
- Practitioner protocols requiring NSF-certified, bioavailable B-vitamin supplementation
Considerations
- High-dose niacin with liver conditions (monitor liver enzymes)
- B6 above 100mg/day long-term (risk of peripheral neuropathy)
- Active cancer treatment (some B vitamins may interfere — consult oncologist)
Compatibility & interactions
Works Well With
Ask Gabriel for personalized stacking recommendations.
Take Separately From
No significant interactions identified. Always consult your healthcare provider.
What to expect over time
Energy Boost
Noticeable improvement in energy levels
Mood & Stress
Reduced stress perception, better coping
Neurological
Improved cognitive clarity and focus
Homocysteine
Measurable homocysteine reduction (cardiovascular marker)
Based on B-complex supplementation research. Water-soluble — yellow urine color is normal and harmless.
Compare the options
Compare B-Vitamin Forms
Methylated vs Standard vs Synthetic
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
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A few useful answers.
Research & further reading
More category questions
What does methylated mean and why does it matter?
Methylated B vitamins are in their active, bioavailable form — your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
Why does my urine turn bright yellow after taking B vitamins?
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
Can I take B-complex in the evening?
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
How do I know if I need B12 specifically?
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Is it safe to take B vitamins every day?
Yes — B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Supplement information is provided for education and is not a substitute for personalized medical advice. Supplements are not intended to diagnose, treat, cure or prevent disease. Read the current product label before use.