Capsules · 60 capsules
Serving Size:
One Capsule
Amount Per Serving:
Thiamin (as Thiamin HCl) ... 110 mg
Riboflavin (as Riboflavin 5’-Phosphate Sodium) ... 10 mg
Niacin (130 mg as Niacinamide and 10 mg as Niacin) ... 140 mg
Vitamin B6 (as Pyridoxal 5’-Phosphate) ... 10 mg
Folate (400 mcg as L-5-Methyltetrahydrofolate† from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt) ... 667 mcg DFE
Vitamin B12 (as Methylcobalamin) ... 400 mcg
Biotin ... 400 mcg
Pantothenic Acid (as Calcium Pantothenate) ... 110 mg
Choline (as Choline Citrate) ... 28 mg
Other Ingredients:
Hypromellose (derived from cellulose) capsule, microcrystalline cellulose, calcium laurate, leucine, magnesium citrate, silicon dioxide
ALLERGY WARNING
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
PREGNANCY
If pregnant, consult your health professional before using this product.
INTERACTIONS
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrent with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, this folate source has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.
Take 1 capsule one to three times daily or as recommended by your health professional.
Open original label
Source: Fullscript supplier catalog · September 04, 2026. Formulas and labels can change. Check the packaging you receive.
Thorne's Basic B Complex delivers a full-spectrum blend of B vitamins in their active, coenzyme forms, including riboflavin 5'-phosphate, pyridoxal 5'-phosphate, and methylfolate, supporting energy metabolism, neurological function, and red blood cell production. Formulated for individuals who may have difficulty converting standard B vitamins into their usable forms.
Why It's Worth Considering: Thorne is a practitioner-preferred brand known for rigorous manufacturing standards; using active coenzyme forms rather than cheaper synthetic precursors may improve utilization for those with common methylation variants like MTHFR.
Take 1 capsule one to three times daily or as recommended by your health professional.
| Feature | Methylated (active) | Standard | Synthetic (cheap) |
|---|---|---|---|
| B12 Form | Methylcobalamin | Hydroxocobalamin | Cyanocobalamin |
| Folate Form | 5-MTHF (methylfolate) | Folinic acid | Folic acid (synthetic) |
| B6 Form | P-5-P (pyridoxal-5-phosphate) | Pyridoxal | Pyridoxine HCl |
| Best For | MTHFR variants, optimal absorption | General use | Budget (requires conversion) |
| MTHFR Safe | Yes — bypasses mutation | Mostly yes | No — cannot be converted by 40% of population |
Methylated B vitamins are in their active, bioavailable form, your body can use them immediately without conversion. About 40% of the population has MTHFR gene variants that impair conversion of synthetic folic acid to active folate. Methylated forms (methylcobalamin, methylfolate, P-5-P) bypass this issue entirely.
This is completely normal and harmless. Riboflavin (B2) is a bright yellow fluorescent compound. When you take more than your body needs, the excess is excreted in urine, causing the distinctive color. It's actually a sign your body absorbed the B vitamins and is eliminating what it doesn't need.
B vitamins support energy production, so morning dosing is generally recommended. Some people find evening B-complex disrupts sleep due to increased energy. However, B6 and B12 are involved in melatonin production, so individual responses vary. If evening dosing doesn't affect your sleep, it's fine.
Signs of B12 deficiency: fatigue, brain fog, tingling/numbness in extremities, balance issues, mood changes, and pale skin. At-risk groups: vegetarians/vegans (B12 is only in animal foods), adults over 50 (reduced absorption), and those taking metformin or PPIs (which deplete B12). A serum B12 test plus methylmalonic acid (more sensitive) can confirm.
Yes, B vitamins are water-soluble, meaning excess is excreted daily. No accumulation risk at standard supplement doses. The exception is B6 (pyridoxine): chronic doses above 100mg/day can cause peripheral neuropathy (nerve damage). The P-5-P form is safer at higher doses than pyridoxine HCl.
Ask Gabriel for personalized stacking recommendations.
No significant interactions identified. Always consult your healthcare provider.
† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
